matai-resinol, matairesinol
| Name | Matairesinol | ||
| PubChem CID | 119205 | ||
| Molecular Weight | 358.4g/mol | ||
| Synonyms |
matai-resinol, matairesinol |
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| Formula | C₂₀H₂₂O₆ | ||
| SMILES | COC1=C(C=CC(=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)O | ||
| InChI | 1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1 | ||
| InChIKey | MATGKVZWFZHCLI-LSDHHAIUSA-N | ||
| CAS Number | 580-72-3 | ||
| ChEMBL ID | CHEMBL425148 | ||
| ChEBI ID | CHEBI:6698 | ||
| Herb ID | HBIN034543 | ||
| Drug Bank ID | DB04200 | ||
| KEGG ID | C10682 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ShaJi | ||
| Use Part | Fruit | ||
| Habitat | BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, SiChuan, XiZang | ||
| Flavor | Sour, Astringent | ||
| Meridian Tropism | Spleen, Stomach, Lung, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Elaeagnaceae
-->Genus: Hippophae
-->Species: Hippophae rhamnoides
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| Chineses Pinyin | MaWeiSongYe | ||
| Use Part | Leaf | ||
| Flavor | Sweet, Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Pinales
-->Family: Pinaceae
-->Genus: Pinus
-->Species: Pinus massoniana
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| Chineses Pinyin | YiYeTieShan | ||
| Use Part | Root, Leaf | ||
| Habitat | Canada, America | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Pinales
-->Family: Pinaceae
-->Genus: Tsuga
-->Species: Tsuga heterophylla
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| Chineses Pinyin | LiaoGeWang | ||
| Use Part | Root | ||
| Flavor | Pungent; Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malvales
-->Family: Thymelaeaceae
-->Genus: Wikstroemia
-->Species: Wikstroemia indica
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| Pair Name | Matairesinol, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Mitochondrial dysfunction | |||
| Gene Regulation | Up-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | FOXM1 | hsa2305 | |
| Up-regulation | Phosphorylation | MAPK14 | hsa1432 | |
| Down-regulation | Expression | PCNA | hsa5111 | |
| Down-regulation | Expression | PLAU | hsa5328 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | MIA PaCa-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0428 |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 | |
| Result | Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells | |||
