Pair Name	Beta-Elemene, Bevacizumab
Partner Name	Beta-Elemene
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	MKI67	hsa4288
	Down-regulation	Expression	PECAM1	hsa5175
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	HCT-116 cells in the logarithmic growth phase were selected and suspended in PBS after 0.25% pancreatic enzyme digestion (cell concentration: 1×10⁷/mL, living cells >95% after trypan blue staining). Nude mice were intraperitoneally injected with 0.2 mL of the cell suspension (total, 2×106 cells/mice) in the right axilla.
Result	Bevacizumab exerts a synergistic effect with β-elemene in suppressing the growth of tumors derived from HCT-116 cells, and the related mechanisms may include the inhibition of tumor cell proliferation and tumor angiogenesis and the promotion of tumor cell apoptosis.

Pair Name	Astragaloside IV, Bevacizumab
Partner Name	Astragaloside IV
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BECN1	hsa8678
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	This paper demonstrates that AST-IV enhances the effect of BV on inhibiting proliferation and promoting apoptosis of lung adenocarcinoma cells through inhibiting autophagy pathway.