isodeoxyelephantopin
| Name | Isodeoxyelephantopin | ||
| PubChem CID | 38359583 | ||
| Molecular Weight | 344.4g/mol | ||
| Synonyms |
isodeoxyelephantopin |
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| Formula | C₁₉H₂₀O₆ | ||
| SMILES | CC1=CC2C(C(CC3=CC(C1)OC3=O)OC(=O)C(=C)C)C(=C)C(=O)O2 | ||
| InChI | 1S/C19H20O6/c1-9(2)17(20)24-15-8-12-7-13(23-19(12)22)5-10(3)6-14-16(15)11(4)18(21)25-14/h6-7,13-16H,1,4-5,8H2,2-3H3/b10-6+/t13-,14+,15-,16-/m0/s1 | ||
| InChIKey | JMUOPRSXUVOHFE-MCYOVBASSA-N | ||
| CAS Number | 29307-03-7 | ||
| KEGG ID | C09388 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZiSuiHuai | ||
| Use Part | Leaf | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, ShanDong, AnHui, JiangSu, HeNan, HuBei, GuangXi, SiChuan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Amorpha
-->Species: Amorpha fruticosa
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| Pair Name | Isodeoxyelephantopin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Expression | ROS1 | hsa6098 |
| Down-regulation | Activity | TXNRD1 | hsa7296 | |
| Up-regulation | Activity | MAPK8 | hsa5599 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| In Vivo Model | HCT116 cells (5×10⁶ cells in 100 μl of phosphate-buffered saline) were injected subcutaneously into the right back of nude mice. | |||
| Result | Our study provide a preclinical proof-of-concept for ESI as a potential strategy for colon cancer treatment. | |||
