TOP
Nav Bar
  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Quercitrin
PubChem CID 5280459
Molecular Weight 448.4g/mol
Synonyms

quercetin 3-O-alpha-L-rhamnopyranoside, quercetin 3-O-alpha-L-rhamnoside, quercetin 3-O-alpha-rhamnopyranoside, quercetin 3-O-L-rhamnoside, quercetin 3-O-rhamnopyranoside, quercetin 3-O-rhamnoside, quercetin 3-rhamnopyranoside, quercetin 3-rhamnoside, quercetin-3-L-rhamnoside, quercetin-3-O-alpha-rhamnosid, quercetin-3-O-alpha-rhamnoside, quercetrin, quercimelin, quercitrin, quercitroside, thujin
Formula C₂₁H₂₀O₁₁
SMILES CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
InChI 1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-26,28-29H,1H3/t7-,15-,17+,18+,21-/m0/s1
InChIKey OXGUCUVFOIWWQJ-HQBVPOQASA-N
CAS Number 522-12-3
ChEMBL ID CHEMBL82242
ChEBI ID CHEBI:17558
Herb ID HBIN041726
KEGG ID C01750
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
Download
2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Euphorbia pekinensis Cold
Chineses Pinyin JingDaJi
Use Part Root
Habitat JiangSu, SiChuan, JiangXi, GuangXi
Flavor Bitter
Meridian Tropism Lung, Spleen, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Malpighiales
　　　　-->Family: Euphorbiaceae
　　　　　-->Genus: Euphorbia
　　　　　　-->Species: Euphorbia pekinensis
(2) Rhododendron dauricum Cold
Chineses Pinyin ManShanHong
Use Part Leaf
Habitat HeiLongJiang, JiLin, XinJiang
Flavor Pungent, Bitter
Meridian Tropism Lung, Spleen
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Ericales
　　　　-->Family: Ericaceae
　　　　　-->Genus: Rhododendron
　　　　　　-->Species: Rhododendron dauricum
(3) Solidago decurrens Cool
Chineses Pinyin YiZhiHuangHua
Use Part Whole Herb
Habitat JiangSu, ZheJiang, JiangXi, HuNan, HuBei, GuangXi, GuangDong, SiChuan, GuiZhou
Flavor Pungent, Bitter
Meridian Tropism Lung, Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asterales
　　　　-->Family: Asteraceae
　　　　　-->Genus: Solidago
　　　　　　-->Species: Solidago decurrens
(4) Polygonum aviculare Cold
Chineses Pinyin BianXu
Use Part Aerial Parts
Habitat China
Flavor Bitter
Meridian Tropism Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Caryophyllales
　　　　-->Family: Polygonaceae
　　　　　-->Genus: Polygonum
　　　　　　-->Species: Polygonum aviculare
(5) Persicaria acuminata Cold
Chineses Pinyin HuZhang
Use Part Rhizome
Habitat Shaanxi, GanSu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuBei, HuNan, SiChuan
Flavor Mildly bitter
Meridian Tropism Liver, Gallbladder, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Caryophyllales
　　　　-->Family: Polygonaceae
　　　　　-->Genus: Persicaria
　　　　　　-->Species: Persicaria acuminata
(6) Saururus chinensis Cold
Chineses Pinyin SanBaiCao
Use Part Rhizome Or Whole Plant
Habitat HeBei, ShanDong, AnHui, JiangSu, ZheJiang, GuangDong, HuNan, HuBei, JiangXi, SiChuan
Flavor Sweet, Pungent
Meridian Tropism Lung, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Piperales
　　　　-->Family: Saururaceae
　　　　　-->Genus: Saururus
　　　　　　-->Species: Saururus chinensis
(7) Houttuynia cordata Cold
Chineses Pinyin YuXingCao
Use Part Aerial Parts
Habitat JiangSu, ZheJiang, JiangXi, AnHui, SiChuan, YunNan, GuiZhou, GuangDong, GuangXi
Flavor Pungent
Meridian Tropism Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Piperales
　　　　-->Family: Saururaceae
　　　　　-->Genus: Houttuynia
　　　　　　-->Species: Houttuynia cordata
(8) Taxillus chinensis Even
Chineses Pinyin SangJiSheng
Use Part Stem And Branch-Leaf
Habitat GuangXi, GuangDong
Flavor Bitter, Sweet
Meridian Tropism Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Santalales
　　　　-->Family: Loranthaceae
　　　　　-->Genus: Taxillus
　　　　　　-->Species: Taxillus chinensis
(9) Hypericum japonicum Cool
Chineses Pinyin DiErCao
Use Part Whole Herb
Habitat HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor Sweet, Mildly bitter
Meridian Tropism Liver, Gallbladder, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Malpighiales
　　　　-->Family: Hypericaceae
　　　　　-->Genus: Hypericum
　　　　　　-->Species: Hypericum japonicum
(10) Japanese Ardisia Even
Chineses Pinyin AiDiCha
Use Part Whole Herb
Habitat HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor Pungent, Mildly bitter
(11) Ardisia japonica Even
Chineses Pinyin ZiJinNiu
Use Part Stem, Leaf
Habitat China
Flavor Pungent
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Ericales
　　　　-->Family: Primulaceae
　　　　　-->Genus: Ardisia
　　　　　　-->Species: Ardisia japonica
(12) Ginkgo bilobe Even
Chineses Pinyin BaiGuoYe
Use Part Leaf
Habitat China
Flavor Bitter, Sweet, Astringent
Meridian Tropism Heart, Lung, Spleen
(13) Alnus japonica Cool
Chineses Pinyin ChiYang
Use Part Bark, Tender Branchlet-Leaf
Habitat HeiLongJiang, JiLin, LiaoNing, ShanDong, JiangSu, GuangDong
Flavor Bitter, Astringent
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Fagales
　　　　-->Family: Betulaceae
　　　　　-->Genus: Alnus
　　　　　　-->Species: Alnus japonica
(14) Polygonum polystachyus Cool
Chineses Pinyin DuoSuiLiao
Use Part Whole Herb
Habitat YunNan, XiZang
Flavor Pungent, Bitter
Meridian Tropism Lung, Spleen, Stomach, Large intestine
(15) Hypericum perforatum Even
Chineses Pinyin GuanYeLianQiao
Use Part Whole Herb With Root
Habitat HeBei, Shaanxi, GanSu, XinJiang, ShanDong, JiangSu, JiangXi, HeNan, HuBei, HuNan, SiChuan, GuiZhou
Flavor Bitter, Astringent
Meridian Tropism Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Malpighiales
　　　　-->Family: Hypericaceae
　　　　　-->Genus: Hypericum
　　　　　　-->Species: Hypericum perforatum
(16) Cremastra appendiculata Cool
Chineses Pinyin GuiDengQing
Use Part Root Stock
Habitat HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan, ShanXi, Shaanxi, GanSu, SiChuan
Flavor Sweet, Mildly pungent
Meridian Tropism Liver, Stomach, Spleen
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asparagales
　　　　-->Family: Orchidaceae
　　　　　-->Genus: Cremastra
　　　　　　-->Species: Cremastra appendiculata
(17) Chamaenerion angusti Even
Chineses Pinyin HongKuaiZi
Use Part Herb
Habitat BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, LiaoNing, JiLin, HeiLongJiang, ShanDong, HeNan, XiZang, Shaanxi, GanSu, QingHai, NingXia, XinJiang, SiChuan, HuBei, YunNan
Flavor Bitter
(18) Polygonum hydropiper Warm
Chineses Pinyin LiaoShi
Use Part Fruit
Habitat China
Flavor Pungent
Meridian Tropism Spleen, Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Caryophyllales
　　　　-->Family: Polygonaceae
　　　　　-->Genus: Persicaria
　　　　　　-->Species: Persicaria hydropiper
(19) Agrimonia pilosa Even
Chineses Pinyin LongYaCao/XianHeCao
Use Part Aerial Parts
Habitat China
Flavor Bitter, Astringent
Meridian Tropism Heart, Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Agrimonia
　　　　　　-->Species: Agrimonia pilosa
(20) Dimocarpus longan Even
Chineses Pinyin LongYanYe
Use Part Leaf
Habitat FuJian, TaiWan, GuangDong, YunNan
Flavor Sweet, Bland
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Sapindales
　　　　-->Family: Sapindaceae
　　　　　-->Genus: Dimocarpus
　　　　　　-->Species: Dimocarpus longan
(21) Erythrina stricta Even
Chineses Pinyin CiTong
Use Part Dried bark or root cortex
Flavor Pungent; Bitter
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Fabales
　　　　-->Family: Fabaceae
　　　　　-->Genus: Erythrina
　　　　　　-->Species: Erythrina stricta
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
Hide/Show
Drug(s) whose efficacy can be enhanced by this phytochemical
Hide/Show
Combination Pair ID: 459
Ref_1
Pair Name Quercitrin, Insulin
Partner Name Insulin
Disease Info [ICD-11: 5A80] Polycystic ovary syndrome Investigative
Gene Regulation Up-regulation Phosphorylation AKT1 hsa207
Up-regulation Phosphorylation MTOR hsa2475
Up-regulation Phosphorylation PIK3CA hsa5290
Up-regulation Expression PM20D1 hsa148811
Up-regulation Phosphorylation PRKAA1 hsa5562
In Vitro Model 3T3-L1 Healthy Mus musculus (Mouse) CVCL_0123
In Vivo Model A total of 48 (specific pathogen-free) SPF female Sprague Dawley rats (aged from six weeks, body weight of 130 –150 g) were uesd in study.
Result PM20D1 and PI3K/Akt were required for lipolysis and endocrine regulation in PCOS-IR to restore ovarian function and maintain normal endocrine metabolism. By upregulating the expression of PM20D1, quercitrin activated the PI3K/Akt signaling pathway, improved adipocyte catabolism, corrected reproductive and metabolic abnormalities, and had a therapeutic effect on PCOS-IR.
04. Reference
No. Title Href
1 Quercitrin alleviates lipid metabolism disorder in polycystic ovary syndrome-insulin resistance by upregulating PM20D1 in the PI3K/Akt pathway. Phytomedicine. 2023 Aug;117:154908. doi: 10.1016/j.phymed.2023.154908. Click
It has been 58127 visits since 2024.08
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang
TOP