2-amino-2-hydroxymethyl-3,4-dihydroxy-14- oxoeicos-6-enoic acid, ISP-1 serine palmitoyltransferase inhibitor, ISP-1 suppressant, myriocin, SPI-1 inhibitor, thermozymocidin
| Name | Myriocin | ||
| PubChem CID | 6438394 | ||
| Molecular Weight | 401.5g/mol | ||
| Synonyms |
2-amino-2-hydroxymethyl-3,4-dihydroxy-14- oxoeicos-6-enoic acid, ISP-1 serine palmitoyltransferase inhibitor, ISP-1 suppressant, myriocin, SPI-1 inhibitor, thermozymocidin |
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| Formula | C₂₁H₃₉NO₆ | ||
| SMILES | CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O | ||
| InChI | 1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1 | ||
| InChIKey | ZZIKIHCNFWXKDY-GNTQXERDSA-N | ||
| CAS Number | 35891-70-4 | ||
| ChEMBL ID | CHEMBL55076 | ||
| ChEBI ID | CHEBI:582124 | ||
| KEGG ID | C19914 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | RouDouKou | ||
| Use Part | Kernel | ||
| Habitat | GuangDong, GuangXi, YunNan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen; Stomach; Large Intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Magnoliales
-->Family: Myristicaceae
-->Genus: Myristica
-->Species: Myristica fragrans
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| Pair Name | Myriocin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Phosphorylation | KDR | hsa3791 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| Down-regulation | Phosphorylation | NOS3 | hsa4846 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| Down-regulation | Phosphorylation | PTK2 | hsa5747 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| In Vitro Model | 3LL | Malignant tumors of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_5653 |
| B16-F10 | Mouse melanoma | Mus musculus (Mouse) | CVCL_0159 | |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| HUVEC-C | Healthy | Homo sapiens (Human) | CVCL_2959 | |
| EA.hy 926 | Healthy | Homo sapiens (Human) | CVCL_3901 | |
| In Vivo Model | B16F10 or LLC cells (5×10⁵ cells in 200 μl) were subcutaneously (s.c.) injected into the flanks of 5–6 weeks-old C57BL/6 J male mice. | |||
| Result | We suggest that myriocin is a novel potent anti-cancer agent that dually targets both VEGFR2 in ECs and IκBα in cancer cells, and exerts more pronounced anti-tumor effects than with either kinase being inhibited alone. | |||
