jervine, jervine, acetate, (3beta,23beta)-isomer
| Name | Jervine | ||
| PubChem CID | 10098 | ||
| Molecular Weight | 425.6g/mol | ||
| Synonyms |
jervine, jervine, acetate, (3beta,23beta)-isomer |
||
| Formula | C₂₇H₃₉NO₃ | ||
| SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1 | ||
| InChI | 1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1 | ||
| InChIKey | CLEXYFLHGFJONT-DNMILWOZSA-N | ||
| CAS Number | 469-59-0 | ||
| ChEMBL ID | CHEMBL186779 | ||
| ChEBI ID | CHEBI:6088 | ||
| Herb ID | HBIN031518 | ||
| KEGG ID | C10811 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | BaiLiLu | ||
| Habitat | ShanXi, HeBei, HeNan, ShanDong, LiaoNing, Shaanxi, SiChuan, JiangSu | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Lung, Stomach, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Melanthiaceae
-->Genus: Veratrum
-->Species: Veratrum nigrum
|
||
| Chineses Pinyin | CiGuoFanLiZhi | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Magnoliales
-->Family: Annonaceae
-->Genus: Annona
-->Species: Annona muricata
|
||
| Chineses Pinyin | LiLu | ||
| Use Part | Root, Rhizome | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, ShanDong, HeNan, HuBei, SiChuan, GuiZhou, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, HuNan, GuangDong, GuangXi, NeiMengGu | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Lung, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Melanthiaceae
-->Genus: Veratrum
-->Species: Veratrum nigrum
|
||
| Chineses Pinyin | MaoYeLiLu | ||
| Use Part | Root, Rhizome | ||
| Habitat | SiChuan, HuBei, HuNan, JiangXi, ZheJiang, TaiWan, YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Melanthiaceae
-->Genus: Veratrum
-->Species: Veratrum grandiflorum
|
||
| Pair Name | Jervine, Decitabine | |||
| Partner Name | Decitabine | |||
| Disease Info | [ICD-11: 2A3Z] | Myelodysplastic syndrome | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Expression | Gli1 | hsa2735 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Down-regulation | Expression | SMO | hsa6608 | |
| In Vitro Model | MUTZ-1 | EBV-related Burkitt lymphoma | Homo sapiens (Human) | CVCL_1431 |
| Result | The Smo inhibitor jervine and its combination with decitabine have a synergistic effect on the proliferation, cell cycle, and apoptosis of MUTZ-1 cells, and its mechanism may be achieved by interfering with the Shh signaling pathway. | |||
