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2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one, 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy, flavone, 3,3',4',5,7-pentahydroxy-, 3-beta-D-glucofuranoside, isoquercetin, isoquercitin, isoquercitrin, isoquercitroside, isotrifoliin, quercetin 3-(beta-D-glucofuranoside), quercetin 3-O-beta-D-glucofuranoside, quercetin-3-glucoside, quercetin-3-O-beta-glucoside, quercetin-3-O-glucoside, trifoliin, trifoliin A

No.	Title	Href
1	Effects of A.marina-Derived Isoquercitrin on TNF-Related Apoptosis-Inducing Ligand Receptor (TRAIL-R) Expression and Apoptosis Induction in Cervical Cancer Cells. Appl Biochem Biotechnol. 2017 Jun;182(2):697-707. doi: 10.1007/s12010-016-2355-6.	`Click`

No.

Title

Href

Effects of A.marina-Derived Isoquercitrin on TNF-Related Apoptosis-Inducing Ligand Receptor (TRAIL-R) Expression and Apoptosis Induction in Cervical Cancer Cells. Appl Biochem Biotechnol. 2017 Jun;182(2):697-707. doi: 10.1007/s12010-016-2355-6.

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Name	Isoquercitrin
PubChem CID	5280804
Molecular Weight	464.4g/mol
Synonyms	2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one, 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy, flavone, 3,3',4',5,7-pentahydroxy-, 3-beta-D-glucofuranoside, isoquercetin, isoquercitin, isoquercitrin, isoquercitroside, isotrifoliin, quercetin 3-(beta-D-glucofuranoside), quercetin 3-O-beta-D-glucofuranoside, quercetin-3-glucoside, quercetin-3-O-beta-glucoside, quercetin-3-O-glucoside, trifoliin, trifoliin A
Formula	C₂₁H₂₀O₁₂
SMILES	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O
InChI	1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17+,18-,21+/m1/s1
InChIKey	OVSQVDMCBVZWGM-QSOFNFLRSA-N
CAS Number	482-35-9
ChEMBL ID	CHEMBL250450
ChEBI ID	CHEBI:68352
Herb ID	HBIN031102
Drug Bank ID	DB12665
KEGG ID	C05623
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	CiTong
Use Part	Dried bark or root cortex
Flavor	Pungent; Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Erythrina 　　　　　　-->Species: Erythrina stricta

Pair Name	Isoquercitrin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	TNFRSF10A	hsa8797
Gene Regulation	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	SiHa	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_0032
Result	We found that isoquercitrin enhances the mRNA expression of TRAIL-Rs, but the percentage of apoptosis was meager, possibly due to the influence of other anti-apoptotic proteins.