neobavaisoflavone
| Name | Neobavaisoflavone | ||
| PubChem CID | 5320053 | ||
| Molecular Weight | 322.4g/mol | ||
| Synonyms |
neobavaisoflavone |
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| Formula | C₂₀H₁₈O₄ | ||
| SMILES | CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C | ||
| InChI | 1S/C20H18O4/c1-12(2)3-4-14-9-13(5-8-18(14)22)17-11-24-19-10-15(21)6-7-16(19)20(17)23/h3,5-11,21-22H,4H2,1-2H3 | ||
| InChIKey | OBGPEBYHGIUFBN-UHFFFAOYSA-N | ||
| CAS Number | 41060-15-5 | ||
| ChEMBL ID | CHEMBL512693 | ||
| ChEBI ID | CHEBI:66614 | ||
| Herb ID | HBIN036562 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BuGuZhi | ||
| Use Part | Fruit | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Kidney; Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Cullen
-->Species: Cullen corylifolium
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| Pair Name | Neobavaisoflavone, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2F7Z] | Glioma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Cleavage | BID | hsa637 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | U-373MG ATCC | Astrocytoma | Homo sapiens (Human) | CVCL_2219 |
| Result | Taken together, our results suggest that NBIF reduces the resistance of cancer cells to TRAIL and that the combination of NBIF and TRAIL may be a new therapeutic strategy for treating TRAIL-resistant glioma cells. | |||
