Cantharides, Cantharidin, Cantharidine
| Name | Cantharidin | ||
| PubChem CID | 5944 | ||
| Molecular Weight | 196.20g/mol | ||
| Synonyms |
Cantharides, Cantharidin, Cantharidine |
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| Formula | C₁₀H₁₂O₄ | ||
| SMILES | CC12C3CCC(C1(C(=O)OC2=O)C)O3 | ||
| InChI | 1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10- | ||
| InChIKey | DHZBEENLJMYSHQ-XCVPVQRUSA-N | ||
| CAS Number | 56-25-7 | ||
| ChEMBL ID | CHEMBL48449 | ||
| ChEBI ID | CHEBI:64213 | ||
| Herb ID | HBIN019611 | ||
| Drug Bank ID | DB12328 | ||
| KEGG ID | C16778 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BanMao | ||
| Use Part | Dry bodies of animals | ||
| Flavor | Pungent | ||
| Meridian Tropism | Liver; Stomach; Kidney | ||
| Species |
>Kingdom: Metazoa
-->Phylum: Arthropoda
-->Class: Insecta
-->Order: Coleoptera
-->Family: Meloidae
-->Genus: Lytta
-->Species: Lytta vesicatoria
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| Pair Name | Cantharidin, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 |
| Result | The results of the present study revealed that cantharidin effectively sensitized cells to TRAIL‑mediated apoptosis and its effects are likely to be mediated by autophagy, the downregulation of c‑FLIP and the upregulation of DR‑5. | |||
