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2',3,4,4'-tetrahydroxychalcone, 2',4',3,4-tetrahydroxychalcone, butein

No.	Title	Href
1	Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med. 2015 Oct;36(4):957-66. doi: 10.3892/ijmm.2015.2324.	`Click`
2	Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch Pharm Res. 2008 Sep;31(9):1179-86. doi: 10.1007/s12272-001-1286-2.	`Click`

No.

Title

Href

Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med. 2015 Oct;36(4):957-66. doi: 10.3892/ijmm.2015.2324.

Click

Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch Pharm Res. 2008 Sep;31(9):1179-86. doi: 10.1007/s12272-001-1286-2.

Click

Name	Butein
PubChem CID	5281222
Molecular Weight	272.25g/mol
Synonyms	2',3,4,4'-tetrahydroxychalcone, 2',4',3,4-tetrahydroxychalcone, butein
Formula	C₁₅H₁₂O₅
SMILES	C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O
InChI	1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
InChIKey	AYMYWHCQALZEGT-ORCRQEGFSA-N
CAS Number	487-52-5
ChEMBL ID	CHEMBL128000
ChEBI ID	CHEBI:3237
Herb ID	HBIN019083
KEGG ID	C08578
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	RouTuoGuo
Flavor	Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Anacardiaceae 　　　　　-->Genus: Semecarpus 　　　　　　-->Species: Semecarpus anacardium

Pair Name	Butein, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	PSMD9	hsa5715
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
In Vivo Model	Suspensions of 1×10⁶ HeLa cells were injected subcutaneously into the flanks of nude mice.
Result	Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a

Pair Name	Butein, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
Result	Our data suggests that combined treatment with butein and TRAIL may provide a safe and effective strategy for treating cancer.