baicalein
| Name | Baicalein | ||
| PubChem CID | 5281605 | ||
| Molecular Weight | 270.24g/mol | ||
| Synonyms |
baicalein |
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| Formula | C₁₅H₁₀O₅ | ||
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O | ||
| InChI | 1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H | ||
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N | ||
| CAS Number | 491-67-8 | ||
| ChEMBL ID | CHEMBL8260 | ||
| ChEBI ID | CHEBI:2979 | ||
| Herb ID | HBIN017508 | ||
| Drug Bank ID | DB16101 | ||
| KEGG ID | C10023 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | CheQianCao | ||
| Use Part | Seed | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver, Kidney, Lung, Small intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Plantaginaceae
-->Genus: Plantago
-->Species: Plantago depressa
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| Chineses Pinyin | BanZhiLian | ||
| Use Part | Whole Grass | ||
| Habitat | GuangDong, ZheJiang, FuJian, TaiWan, GuangXi, HaiNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Lung, Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Scutellaria
-->Species: Scutellaria barbata
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| Chineses Pinyin | ChiShao | ||
| Use Part | Root | ||
| Habitat | Shaanxi, GanSu, QingHai, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Saxifragales
-->Family: Paeoniaceae
-->Genus: Paeonia
-->Species: Paeonia veitchii
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| Chineses Pinyin | BanXia | ||
| Use Part | Tuberoid | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Alismatales
-->Family: Araceae
-->Genus: Pinellia
-->Species: Pinellia ternata
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| Chineses Pinyin | CheQian | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Plantaginaceae
-->Genus: Plantago
-->Species: Plantago asiatica
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| Chineses Pinyin | HuangQin | ||
| Use Part | Root | ||
| Habitat | HeiLongJiang, LiaoNing, NeiMengGu, HeBei, HeNan, GanSu, Shaanxi, ShanXi, ShanDong, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung; Large Intestine; Stomach; Small Intestine; Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Scutellaria
-->Species: Scutellaria baicalensis
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| Pair Name | Baicalein, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis and autophagy | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | IKBKB | hsa3551 | |
| Down-regulation | Activity | KEAP1 | hsa9817 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Down-regulation | Activity | NFE2L2 | hsa4780 | |
| Up-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Phosphorylation | SQSTM1 | hsa8878 | |
| In Vitro Model | MGC-803 | Gastric mucinous adenocarcinoma | Homo sapiens (Human) | CVCL_5334 |
| HGC-27 | Gastric carcinoma | Homo sapiens (Human) | CVCL_1279 | |
| SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 | |
| Result | Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway | |||
| Pair Name | Baicalein, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Phosphorylation | MAPK14 | hsa1432 | |
| Down-regulation | Expression | MMP2 | hsa4313 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Down-regulation | Expression | SLC7A6 | hsa9057 | |
| In Vitro Model | A2780 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0134 |
| A2780/CDDP | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_D619 | |
| T29 | Healthy | Homo sapiens (Human) | CVCL_2G67 | |
| In Vivo Model | Single cell suspensions from A2780, A2780/CDDP, A2780/CDDP shCirSLC7A6 or A2780/CDDP shGFP cells were injected (5.0×10⁶ cells/100 ul in phosphate buffered saline) subcutaneously into the bilateral interscapular region of the mice. | |||
| Result | Treatment with baicalein improved the sensitivity of ovarian cancer cells to cisplatin and inhibited cell proliferation, metastasis and tumor growth | |||
| Pair Name | Baicalein, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| In Vitro Model | 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 |
| In Vivo Model | 100 µl of 1×10⁵ 4T1 cells/mice having minimum passage number were injected subcutaneously at the right lower quadrant near the mammary gland into the animal abdomen. | |||
| Result | Ratiometric codelivery of Paclitaxel and Baicalein loaded nanoemulsion for enhancement of breast cancer treatment. | |||
| Pair Name | Baicalein, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | CDK1 | hsa983 |
| Down-regulation | Phosphorylation | DNM1L | hsa10059 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | PINK1 | hsa65018 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1 | |||
| Pair Name | Baicalein, Docetaxel | |||
| Partner Name | Docetaxel | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Inhibition-->Tumor angiogenesis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | CCNB1 | hsa891 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Expression | CDC25C | hsa995 | |
| Down-regulation | Expression | CDK4 | hsa1019 | |
| Down-regulation | Expression | CDK6 | hsa1021 | |
| Down-regulation | Expression | CTNNB1 | hsa1499 | |
| Up-regulation | Phosphorylation | GSK3B | hsa2932 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner | |||
| Pair Name | Baicalein, Epirubicin | |||
| Partner Name | Epirubicin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis and autophagy | |||
| Gene Regulation | Up-regulation | Expression | ATG7 | hsa10533 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Down-regulation | Expression | TGFB1 | hsa7040 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| WI-38 | Healthy | Homo sapiens (Human) | CVCL_0579 | |
| Result | BTME (200μg/mL) significantly enhanced epirubicin's cytotoxicity against Hep-G2 cells and ameliorated its safety profile. BTME could exert anti-hepatocarcinoma effect by enhancing apoptosis and autophagy | |||
| No. | Title | Href |
|---|---|---|
| 1 | Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner. Phytother Res. 2020 Jan;34(1):104-117. doi: 10.1002/ptr.6501. | Click |
| 2 | Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy. Toxicol In Vitro. 2024 Mar;95:105744. doi: 10.1016/j.tiv.2023.105744. | Click |
| 3 | Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway. Biochem Biophys Res Commun. 2020 Oct 20;531(3):320-327. doi: 10.1016/j.bbrc.2020.07.045. | Click |
| 4 | Baicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A6. J Ovarian Res. 2023 Nov 8;16(1):212. doi: 10.1186/s13048-023-01285-0. | Click |
| 5 | Ratiometric codelivery of Paclitaxel and Baicalein loaded nanoemulsion for enhancement of breast cancer treatment. Int J Pharm. 2023 Aug 25;643:123209. doi: 10.1016/j.ijpharm.2023.123209. | Click |
| 6 | Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1. Mol Cell Biochem. 2023 Jul;478(7):1519-1531. doi: 10.1007/s11010-022-04597-9. | Click |
