| Name | Xanthohumol | ||
| PubChem CID | 639665 | ||
| Molecular Weight | 354.4g/mol | ||
| Synonyms |
(2E)-1-(2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, (2E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-2-propen-1-one, 1-(2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 2,4,4',6-tetrahydroxy-3-(3,3-dimethylallyl)chalcone, desmethylxanthohumol, Xantho-Flav, XanthoFlav, xanthohumol |
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| Formula | C₂₁H₂₂O₅ | ||
| SMILES | CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=CC=C(C=C2)O)O)C | ||
| InChI | 1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+ | ||
| InChIKey | ORXQGKIUCDPEAJ-YRNVUSSQSA-N | ||
| CAS Number | 6754-58-1 | ||
| ChEMBL ID | CHEMBL253896 | ||
| ChEBI ID | CHEBI:66331 | ||
| Herb ID | HBIN048442 | ||
| Drug Bank ID | DB15359 | ||
| KEGG ID | C16417 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | KuShen | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
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| Chineses Pinyin | PiJiuHua | ||
| Use Part | Female-Flower | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, ShanDong | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Cannabaceae
-->Genus: Humulus
-->Species: Humulus lupulus
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| Pair Name | Xanthohumol, Praziquantel | |||
| Partner Name | Praziquantel | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Down-regulation | Expression | CD44 | hsa960 |
| Down-regulation | Phosphorylation | MAPK14 | hsa1432 | |
| Down-regulation | Expression | TFRC | hsa7037 | |
| In Vivo Model | Six- to eight-week-old male Syrian golden hamsters were randomly divided into four groups as followings: group I, Ov infection and NDMA administration (ON); group II, Ov infection and NDMA administration and PZ treatment (ONP); groups III and IV were similar to group I and II, they received 20 μM XN (171 mg/B.W./day) designated as XON and XONP groups, respectively. | |||
| Result | XN administered in combination with PZ could efficiently prevent CCA development and hence provide potential chemopreventive benefits in Ov-induced cholangiocarcinogenesis | |||
