xanthorrhizol, xanthorrizol
| Name | Xanthorrhizol | ||
| PubChem CID | 93135 | ||
| Molecular Weight | 218.33g/mol | ||
| Synonyms |
xanthorrhizol, xanthorrizol |
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| Formula | C₁₅H₂₂O | ||
| SMILES | CC1=C(C=C(C=C1)C(C)CCC=C(C)C)O | ||
| InChI | 1S/C15H22O/c1-11(2)6-5-7-12(3)14-9-8-13(4)15(16)10-14/h6,8-10,12,16H,5,7H2,1-4H3/t12-/m1/s1 | ||
| InChIKey | FKWGCEDRLNNZOZ-GFCCVEGCSA-N | ||
| CAS Number | 30199-26-9 | ||
| ChEMBL ID | CHEMBL460033 | ||
| ChEBI ID | CHEBI:184290 | ||
| Herb ID | HBIN048460 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | MoYao | ||
| Use Part | Balsam | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Burseraceae
-->Genus: Commiphora
-->Species: Commiphora myrrha
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| Chineses Pinyin | GanJiang | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Kidney, Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Zingiber
-->Species: Zingiber officinale
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| Chineses Pinyin | YuJin | ||
| Use Part | Tuberoid | ||
| Habitat | JiangSu, ZheJiang, FuJian, GuangDong, GuangXi, JiangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma wenyujin
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| Chineses Pinyin | LiZhiHe | ||
| Use Part | Fruit | ||
| Habitat | GuangDong, GuangXi, HaiNan, Hongkong , SiChuan, GuiZhou, YunNan, XiZang, ChongQing | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Sapindaceae
-->Genus: Litchi
-->Species: Litchi chinensis
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| Chineses Pinyin | JiuLiXiang | ||
| Use Part | Leaf, Branchlet | ||
| Habitat | TaiWan, FuJian, GuangDong, HaiNan, GuangXi | ||
| Flavor | Pungent, Mildly bitter | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Murraya
-->Species: Murraya exotica
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| Chineses Pinyin | EZhu | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Liver; Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma zedoaria
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| Pair Name | Xanthorrhizol, Tamoxifen | |||
| Partner Name | Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | MAPK14 | hsa1432 |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| In Vivo Model | Using the MCF-7 implanted nude mice model, it was possible to detect significantly increased tumor volumes, a larger tumor size, and increased protein expression of P38 and P27(Kip1) in the xanthorrhizol + tamoxifen group compared to the tamoxifen-alone group. | |||
| Result | It can be concluded that while there is no significant herb-drug interaction between xanthorrhizol and tamoxifen in vitro, there is such an interaction in tumor-bearing mice, which provides important information that affects breast cancer treatment translational research. | |||
