InterPAD - DETAILS

praziquantel, 55268-74-1, Biltricide, Droncit, Pyquiton, Cesol, Embay 8440, Praziquantelum, Cysticide, Distocide, Prazinon, Praziquantelum [INN-Latin], 2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, CCRIS 4114, EMBAY-8440, Praziquantel (Biltricide), 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, EINECS 259-559-6, NSC-757285, BRN 0761557, MLS000038419, DTXSID9021182, UNII-6490C9U457, 2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, MFCD00058531, 135526-78-2, SMR000037139, 2-(cyclohexanecarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, DTXCID501182, Prasiquantel, 6490C9U457, Azinox, 5-24-03-00361 (Beilstein Handbook Reference), Cutter Tape Tabs, BROADLINE COMPONENT PRAZIQUANTEL, NSC 757285, PROFENDER COMPONENT PRAZIQUANTEL, Praziquantel [USAN:USP:INN:BAN:JAN], PRAZIQUANTEL (EMA EPAR: VETERINARY), Praziquantelum (INN-Latin), 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one, PRAZIQUANTEL (MART.), PRAZIQUANTEL [MART.], PRAZIQUANTEL (USP-RS), PRAZIQUANTEL [USP-RS], Cutter, PRAZIQUANTEL (EP MONOGRAPH), PRAZIQUANTEL (USP IMPURITY), PRAZIQUANTEL [EP MONOGRAPH], PRAZIQUANTEL [USP IMPURITY], PRAZIQUANTEL (USP MONOGRAPH), PRAZIQUANTEL [USP MONOGRAPH], 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one, 4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, Biltricide (TN), Praziquantel (USAN:USP:INN:BAN:JAN), (+/-)-Praziquantel, (S)-2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, SR-01000003100, prazicuantel, Prazitech, PraziCleanse, Bay-8440, Praziquantel (JAN/USP/INN), Praziquantel,(S), NCGC00016877-01, Prestwick_402, Praziquantel Tablets, CAS-55268-74-1, Praziquantel 100 microg/mL in Acetonitrile, DACTYMOR, Praziquantel Injection, Spectrum_001119, Opera_ID_378, Droncit Canine Cestocide, Droncit Feline Cestocide, Prestwick0_000260, Prestwick1_000260, Prestwick2_000260, Prestwick3_000260, Spectrum2_001288, Spectrum3_000550, Spectrum4_000482, Spectrum5_001064, PRAZIQUANTEL [MI], PRAZIQUANTEL [INN], PRAZIQUANTEL [JAN], CHEMBL976, Tapeworm Dewormer for Cats, P 4668, PRAZIQUANTEL [USAN], cid_4891, PRAZIQUANTEL [VANDF], Lopac0_000909, Oprea1_163497, SCHEMBL44153, BSPBio_000080, BSPBio_002199, KBioGR_000963, KBioSS_001599, MLS000028528, MLS001201812, MLS001304085, MLS002548849, MLS006011880, DivK1c_000130, PRAZIQUANTEL [WHO-DD], PRAZIQUANTEL [WHO-IP], SPECTRUM1500494, SPBio_001295, SPBio_002299, Praziquantel-(cyclohexyl-d11), BPBio1_000088, Durvet Feline Tape Tabsfor Cats, SCHEMBL16019896, BDBM74574, CHEBI:45267, CHEBI:91583, HMS500G12, KBio1_000130, KBio2_001599, KBio2_004167, KBio2_006735, KBio3_001699, P02BA01, PRAZIQUANTEL [GREEN BOOK], TAPEWORM DEWORMER FOR DOGS, NINDS_000130, GLXC-26256, HMS1568D22, HMS1920J06, HMS2090J19, HMS2092A09, HMS2095D22, HMS3259K07, HMS3262F20, HMS3655O19, HMS3712D22, Pharmakon1600-01500494, PRAZIQUANTEL [ORANGE BOOK], Praziquantel for system suitability, AMY16524, BCP17829, BCP28525, BCP30228, HY-B0244, WZB34336, Droncit 5.68% Injectible Solution, Tox21_110660, Tox21_201950, Tox21_302927, Tox21_500909, CCG-39773, NSC757285, Praziquantel, anthelminic, neurogenic, s1691, STK030186, PRAZIQUANTELUM [WHO-IP LATIN], AKOS000541869, AKOS016398525, Tox21_110660_1, AC-8426, DB01058, LP00909, NC00468, SB49202, SDCCGSBI-0050884.P005, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazinoe(2,1a)isoquinolin-4-one, IDI1_000130, NCGC00015818-04, NCGC00015818-05, NCGC00015818-06, NCGC00015818-07, NCGC00015818-08, NCGC00015818-11, NCGC00015818-12, NCGC00015818-14, NCGC00015818-15, NCGC00015818-26, NCGC00089733-02, NCGC00089733-03, NCGC00089733-04, NCGC00089733-05, NCGC00256422-01, NCGC00259499-01, NCGC00261594-01, AS-12459, BP166192, PRAZIQUANTEL COMPONENT OF BROADLINE, PRAZIQUANTEL COMPONENT OF PROFENDER, SY052322, SBI-0050884.P004, DB-052707, (S)-Praziquantel; Praziquantel, (S)-Isomer, AB00052075, EU-0100909, FT-0630676, FT-0673999, NS00010534, P2125, SW196645-3, 1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, Worm and Parasites Aquarium Cure Program Salt, 2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-, C07367, D00471, EN300-123768, Worm and Parasites Aquarium Cure Program Fresh, AB00052075-13, AB00052075-15, AB00052075_16, AB00052075_17, Praziquantel, VETRANAL(TM), analytical standard, A830562, Q424145, Prazi-C Tablets (OTC), Praziquantel Tablets (Rx), Praziquantel, Antibiotic for Culture Media Use Only, Q-201612, SR-01000003100-3, SR-01000003100-5, SR-01000003100-7, BRD-A21858158-001-05-2, BRD-A21858158-001-16-9, SR-01000003100-16, F0037-0136, Z1554103331, Praziquantel, European Pharmacopoeia (EP) Reference Standard, Praziquantel, United States Pharmacopeia (USP) Reference Standard, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro- 4H-pyrazino[2,1-a]-isoquinolin-4-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-aisoquinolin-4-one, 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, Praziquantel for system suitability, European Pharmacopoeia (EP) Reference Standard, Praziquantel, Pharmaceutical Secondary Standard; Certified Reference Material, Droncit Canine Cestocide Tablets, Droncit Feline Cestocide Tablets, Praziquantel 34 (Rx), Tapeworm Dewormer for Cats (OTC), Tapeworm Dewormer for Dogs (OTC), InChI=1/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H

Name	Praziquantel
PubChem CID	4891
Molecular Weight	312.4g/mol
Synonyms	praziquantel, 55268-74-1, Biltricide, Droncit, Pyquiton, Cesol, Embay 8440, Praziquantelum, Cysticide, Distocide, Prazinon, Praziquantelum [INN-Latin], 2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, CCRIS 4114, EMBAY-8440, Praziquantel (Biltricide), 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, EINECS 259-559-6, NSC-757285, BRN 0761557, MLS000038419, DTXSID9021182, UNII-6490C9U457, 2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, MFCD00058531, 135526-78-2, SMR000037139, 2-(cyclohexanecarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, DTXCID501182, Prasiquantel, 6490C9U457, Azinox, 5-24-03-00361 (Beilstein Handbook Reference), Cutter Tape Tabs, BROADLINE COMPONENT PRAZIQUANTEL, NSC 757285, PROFENDER COMPONENT PRAZIQUANTEL, Praziquantel [USAN:USP:INN:BAN:JAN], PRAZIQUANTEL (EMA EPAR: VETERINARY), Praziquantelum (INN-Latin), 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one, PRAZIQUANTEL (MART.), PRAZIQUANTEL [MART.], PRAZIQUANTEL (USP-RS), PRAZIQUANTEL [USP-RS], Cutter, PRAZIQUANTEL (EP MONOGRAPH), PRAZIQUANTEL (USP IMPURITY), PRAZIQUANTEL [EP MONOGRAPH], PRAZIQUANTEL [USP IMPURITY], PRAZIQUANTEL (USP MONOGRAPH), PRAZIQUANTEL [USP MONOGRAPH], 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one, 4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, Biltricide (TN), Praziquantel (USAN:USP:INN:BAN:JAN), (+/-)-Praziquantel, (S)-2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, SR-01000003100, prazicuantel, Prazitech, PraziCleanse, Bay-8440, Praziquantel (JAN/USP/INN), Praziquantel,(S), NCGC00016877-01, Prestwick_402, Praziquantel Tablets, CAS-55268-74-1, Praziquantel 100 microg/mL in Acetonitrile, DACTYMOR, Praziquantel Injection, Spectrum_001119, Opera_ID_378, Droncit Canine Cestocide, Droncit Feline Cestocide, Prestwick0_000260, Prestwick1_000260, Prestwick2_000260, Prestwick3_000260, Spectrum2_001288, Spectrum3_000550, Spectrum4_000482, Spectrum5_001064, PRAZIQUANTEL [MI], PRAZIQUANTEL [INN], PRAZIQUANTEL [JAN], CHEMBL976, Tapeworm Dewormer for Cats, P 4668, PRAZIQUANTEL [USAN], cid_4891, PRAZIQUANTEL [VANDF], Lopac0_000909, Oprea1_163497, SCHEMBL44153, BSPBio_000080, BSPBio_002199, KBioGR_000963, KBioSS_001599, MLS000028528, MLS001201812, MLS001304085, MLS002548849, MLS006011880, DivK1c_000130, PRAZIQUANTEL [WHO-DD], PRAZIQUANTEL [WHO-IP], SPECTRUM1500494, SPBio_001295, SPBio_002299, Praziquantel-(cyclohexyl-d11), BPBio1_000088, Durvet Feline Tape Tabsfor Cats, SCHEMBL16019896, BDBM74574, CHEBI:45267, CHEBI:91583, HMS500G12, KBio1_000130, KBio2_001599, KBio2_004167, KBio2_006735, KBio3_001699, P02BA01, PRAZIQUANTEL [GREEN BOOK], TAPEWORM DEWORMER FOR DOGS, NINDS_000130, GLXC-26256, HMS1568D22, HMS1920J06, HMS2090J19, HMS2092A09, HMS2095D22, HMS3259K07, HMS3262F20, HMS3655O19, HMS3712D22, Pharmakon1600-01500494, PRAZIQUANTEL [ORANGE BOOK], Praziquantel for system suitability, AMY16524, BCP17829, BCP28525, BCP30228, HY-B0244, WZB34336, Droncit 5.68% Injectible Solution, Tox21_110660, Tox21_201950, Tox21_302927, Tox21_500909, CCG-39773, NSC757285, Praziquantel, anthelminic, neurogenic, s1691, STK030186, PRAZIQUANTELUM [WHO-IP LATIN], AKOS000541869, AKOS016398525, Tox21_110660_1, AC-8426, DB01058, LP00909, NC00468, SB49202, SDCCGSBI-0050884.P005, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazinoe(2,1a)isoquinolin-4-one, IDI1_000130, NCGC00015818-04, NCGC00015818-05, NCGC00015818-06, NCGC00015818-07, NCGC00015818-08, NCGC00015818-11, NCGC00015818-12, NCGC00015818-14, NCGC00015818-15, NCGC00015818-26, NCGC00089733-02, NCGC00089733-03, NCGC00089733-04, NCGC00089733-05, NCGC00256422-01, NCGC00259499-01, NCGC00261594-01, AS-12459, BP166192, PRAZIQUANTEL COMPONENT OF BROADLINE, PRAZIQUANTEL COMPONENT OF PROFENDER, SY052322, SBI-0050884.P004, DB-052707, (S)-Praziquantel; Praziquantel, (S)-Isomer, AB00052075, EU-0100909, FT-0630676, FT-0673999, NS00010534, P2125, SW196645-3, 1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, Worm and Parasites Aquarium Cure Program Salt, 2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-, C07367, D00471, EN300-123768, Worm and Parasites Aquarium Cure Program Fresh, AB00052075-13, AB00052075-15, AB00052075_16, AB00052075_17, Praziquantel, VETRANAL(TM), analytical standard, A830562, Q424145, Prazi-C Tablets (OTC), Praziquantel Tablets (Rx), Praziquantel, Antibiotic for Culture Media Use Only, Q-201612, SR-01000003100-3, SR-01000003100-5, SR-01000003100-7, BRD-A21858158-001-05-2, BRD-A21858158-001-16-9, SR-01000003100-16, F0037-0136, Z1554103331, Praziquantel, European Pharmacopoeia (EP) Reference Standard, Praziquantel, United States Pharmacopeia (USP) Reference Standard, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro- 4H-pyrazino[2,1-a]-isoquinolin-4-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-aisoquinolin-4-one, 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, Praziquantel for system suitability, European Pharmacopoeia (EP) Reference Standard, Praziquantel, Pharmaceutical Secondary Standard; Certified Reference Material, Droncit Canine Cestocide Tablets, Droncit Feline Cestocide Tablets, Praziquantel 34 (Rx), Tapeworm Dewormer for Cats (OTC), Tapeworm Dewormer for Dogs (OTC), InChI=1/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H
Drug Type	Small molecule
Formula	C₁₉H₂₄N₂O₂
SMILES	C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
InChI	1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
InChIKey	FSVJFNAIGNNGKK-UHFFFAOYSA-N
CAS Number	55268-74-1
ChEMBL ID	CHEMBL976
ChEBI ID	CHEBI:91583
TTD ID	D0L9ZR
Drug Bank ID	DB01058
KEGG ID	C07367
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Xanthohumol, Praziquantel
Partner Name	Xanthohumol
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Phosphorylation	MAPK14	hsa1432
	Down-regulation	Expression	TFRC	hsa7037
In Vivo Model	Six- to eight-week-old male Syrian golden hamsters were randomly divided into four groups as followings: group I, Ov infection and NDMA administration (ON); group II, Ov infection and NDMA administration and PZ treatment (ONP); groups III and IV were similar to group I and II, they received 20 μM XN (171 mg/B.W./day) designated as XON and XONP groups, respectively.
Result	XN administered in combination with PZ could efficiently prevent CCA development and hence provide potential chemopreventive benefits in Ov-induced cholangiocarcinogenesis