oleandrin
| Name | Oleandrin | ||
| PubChem CID | 11541511 | ||
| Molecular Weight | 576.7g/mol | ||
| Synonyms |
oleandrin |
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| Formula | C₃₂H₄₈O₉ | ||
| SMILES | CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O | ||
| InChI | 1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1 | ||
| InChIKey | JLPDBLFIVFSOCC-XYXFTTADSA-N | ||
| CAS Number | 465-16-7 | ||
| ChEMBL ID | CHEMBL4285883 | ||
| ChEBI ID | CHEBI:59030 | ||
| Herb ID | HBIN037934 | ||
| Drug Bank ID | DB12843 | ||
| KEGG ID | C19987 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | QingMingHua | ||
| Use Part | Root, Leaf | ||
| Habitat | YunNan, GuangXi, GuangDong, FuJian | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Apocynaceae
-->Genus: Beaumontia
-->Species: Beaumontia grandiflora
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| Chineses Pinyin | JiaZhuTao | ||
| Use Part | Leaf or bark | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Apocynaceae
-->Genus: Nerium
-->Species: Nerium oleander
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| Pair Name | Oleandrin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Activity | ELK1 | hsa2002 | |
| Up-regulation | Activity | MAPK14 | hsa1432 | |
| In Vitro Model | 143B | Osteosarcoma | Homo sapiens (Human) | CVCL_2270 |
| U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 | |
| MG-63 | Osteosarcoma | Homo sapiens (Human) | CVCL_0426 | |
| Result | The combination of oleandrin with cisplatin exerts a synergistic antitumor effect in osteosarcoma, which relates to the activation of the p38 MAPK pathway. | |||
