Pair Name	Juglone, Indomethacin
Phytochemical Name	Juglone
Anticancer drug Name	Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	IND and JUG reduce the inflammatory activity and induce apoptotic cell death, while JUG effectively prevents IND induced gastric ulceration. These findings establish that a combination of IND + JUG may serve as a promising treatment regimen for colon cancer.

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Apigenin enhances TRAIL-induced antitumor activity in NSCLC cells by APG via inhibition of the NF-kappaB, AKT and ERK prosurvival regulators

Pair Name	Baicalin, Doxorubicin
Phytochemical	Baicalin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	This study demonstrate that the effect of baicalin on Dox treatment could enhance cytotoxicity toward breast cancer cells via the ROS/[Ca2+]i-mediated intrinsic apoptosis pathway-thus potentially lessening the required dosage of doxorubicin, and further exploring associated mechanisms in combined treatments for breast cancer clinical interventions in the future.

Pair Name	Beta-Elemene, Cisplatin
Phytochemical	Beta-Elemene
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	These results define a pathway of procaspase‑3-β-ELE function that involves decreased mitochondrial membrane potential, leading to apoptosis triggered by the release of cytochrome c into the cytoplasm and the modulation of apoptosis-related genes. The reversal of drug resistance of the A549/DDP cell line by β-ELE may be derived from its effect in inducing apoptosis.

Pair Name	Betulin, Arsenic oxide (As2O3)
Phytochemical	Betulin
Drug	Arsenic oxide (As2O3)
Disease Info	[ICD-11: 2D11]	Neuroblastoma		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	The novel combination of As2O3 plus betulin has the potential to serve as a practical anti-neuroblastoma drug.

Pair Name	Bufalin, Fluorouracil
Phytochemical	Bufalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Bufalin in combination with 5-FU may induce a higher level of apoptosis compared with monotherapy, and the combination mat be a potential therapeutic strategy for the treatment of colorectal cancer.

Pair Name	Bufalin, Sorafenib
Phytochemical	Bufalin
Drug	Sorafenib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Sorafenib in combination with bufalin shows more potent cytotoxic effects and cell apoptosis than sorafenib or bufalin treatment alone in NCI-H292 cells. The combined treatment significantly enhanced apoptotic cell death in NCI-H292 lung cancer cells by activating ROS-, mitochondria-, and caspase-signaling pathways in vitro.

Pair Name	Carnosic acid, Tamoxifen
Phytochemical	Carnosic acid
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.

Pair Name	Cucurbitacin B, Cisplatin
Phytochemical	Cucurbitacin B
Drug	Cisplatin
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Down-regulation	Bcl2-associated agonist of cell death		Phosphorylation
Result	Our results showed that CuB may be a new agent that can support conventional treatment in bladder cancer. Our study is important in terms of enlightening new pathways and developing new treatment methods in the treatment of bladder cancer.

Pair Name	Epigallocatechin gallate, Fluorouracil
Phytochemical	Epigallocatechin gallate
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Bcl2-associated agonist of cell death		Expression
Result	EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

Pair Name	Furanodiene, Doxorubicin
Phytochemical	Furanodiene
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	These results indicate that furanodiene may be a promising and safety natural agent for cancer adjuvant therapy in the future.

Pair Name	Gamma-Tocotrienol, Cisplatin
Phytochemical	Gamma-Tocotrienol
Drug	Cisplatin
Disease Info	[ICD-11: 2C51]	Mesothelioma		Investigative
Regulate Info	Down-regulation	Bcl2-associated agonist of cell death		Phosphorylation
Result	These results suggest that the combination therapy of cisplatin with TRF is a plausible strategy for achieving tolerance for the chemotherapeutic agent in MM therapy.

Pair Name	Gossypol, Zoledronic acid
Phytochemical	Gossypol
Drug	Zoledronic acid
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins.

Pair Name	Juglone, Indomethacin
Phytochemical	Juglone
Drug	Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	A combination of both was shown to be more effective, suggesting that juglone may be considered for therapeutic intervention of colon cancer.

Pair Name	Luteolin, Celecoxib
Phytochemical	Luteolin
Drug	Celecoxib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	These results demonstrate the synergistic anti-tumor effect of the celecoxib and luteolin combination treatment in different four breast cancer cell lines, thus introducing the possibility of this combination as a new treatment modality.

Pair Name	Luteolin, Erlotinib
Phytochemical	Luteolin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.

Pair Name	Morin, MST312
Phytochemical	Morin
Drug	MST312
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Phosphorylation
Result	Our study suggests that novel targeted-therapy can be implemented by using flavonoid morin and telomerase inhibitor MST‑312 for improved cancer prognosis.

Pair Name	Naringenin, AMG-951
Phytochemical	Naringenin
Drug	AMG-951
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.

Pair Name	Oridonin, Venetoclax
Phytochemical	Oridonin
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Bcl2-associated agonist of cell death		Expression
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.

Pair Name	OSW-1, Carboplatin
Phytochemical	OSW-1
Drug	Carboplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Our data revealed the mode of action and molecular mechanism underlying the effect of OSW-1 against TNBC, and provided a useful guidance for improving the sensitivity of TNBC cells to conventional chemotherapeutic drugs, which warrants further investigation.

Pair Name	Phenethyl isothiocyanate, Irinotecan
Phytochemical	Phenethyl isothiocyanate
Drug	Irinotecan
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.

Pair Name	Shikonin, Gefitinib
Phytochemical	Shikonin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Bcl2-associated agonist of cell death		Expression
Result	Shikonin-induced cell apoptosis is closely associated with ROS elevation in the cells. These findings indicate that Shikonin can be an effective small molecule treating gefitinib-resistant NSCLC.