Pair Name	(S)-10-Hydroxycamptothecin, Crizotinib
Phytochemical	(S)-10-Hydroxycamptothecin
Drug	Crizotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Pair Name	Alpha-Hederin, Cisplatin
Phytochemical	Alpha-Hederin
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	α-Hederin enhances cisplatin-induced anti-tumour effects in GC both in vitro and in vivo by promoting the accumulation of ROS and decreasing MMP. Our data strongly suggested that α-Hederin is a promising candidate for intervention in gastric cancer.

Pair Name	Apigenin, Doxorubicin
Phytochemical	Apigenin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells

Pair Name	Baicalin, Doxorubicin
Phytochemical	Baicalin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	This study demonstrate that the effect of baicalin on Dox treatment could enhance cytotoxicity toward breast cancer cells via the ROS/[Ca2+]i-mediated intrinsic apoptosis pathway-thus potentially lessening the required dosage of doxorubicin, and further exploring associated mechanisms in combined treatments for breast cancer clinical interventions in the future.

Pair Name	Berbamine, Cisplatin
Phytochemical	Berbamine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	These findings indicate that Ber might be a promising adjuvant for enhancing the cancer cell killing effect of chemotherapy via the inhibition of autophagy. In this process, Nox2 might be a significant mediator of Ber-induced aberrant lysosomal acidification.

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Celastrol, Tamoxifen
Phytochemical	Celastrol
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	CEL can promote apoptosis and enhance the TAM sensitivity in TNBC treatment through a mitochondria-mediated pathway.

Pair Name	Cepharanthine, Epirubicin
Phytochemical	Cepharanthine
Drug	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis

Pair Name	Dehydrobruceine B, Cisplatin
Phytochemical	Dehydrobruceine B
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	These results generated a rationale for further investigation of DHB combined with CDDP as a potential therapeutic strategy in lung cancer.

Pair Name	Delta-Tocotrienol, Cisplatin
Phytochemical	Delta-Tocotrienol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

Pair Name	Eugenol, Cisplatin
Phytochemical	Eugenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Eugenol showed antiproliferative and cytotoxic effects via apoptosis and also synergism with cisplatin and ionizing radiation in the human cervical cancer cell line.

Pair Name	Gambogenic acid, Fluorouracil
Phytochemical	Gambogenic acid
Drug	Fluorouracil
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	These mechanisms may be due to the toxicity of targeted toxin to mitochondria via the mitochondrial pathway.

Pair Name	Gamma-Tocotrienol, Docetaxel
Phytochemical	Gamma-Tocotrienol
Drug	Docetaxel
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.

Pair Name	Glucosinalbate, Doxorubicin
Phytochemical	Glucosinalbate
Drug	Doxorubicin
Disease Info	[ICD-11: 2C90]	Ehrlich ascites carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	The present study clearly suggested therapeutic benefit of I3C in combination with DOX by augmenting anticancer efficacy and diminishing toxicity to the host.

Pair Name	Homoharringtonine, Suberoylanilide hydroxamic acid (SAHA)
Phytochemical	Homoharringtonine
Drug	Suberoylanilide hydroxamic acid (SAHA)
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	The synergistic effect between HHT and SAHA was blocked partially using a specific anti‑TRAIL antibody. The combination therapy was also found to significantly inhibit the growth of leukemia xenografts in vivo with enhanced apoptosis. These results indicate that, by regulating the induction of TRAIL and activation of the TRAIL apoptotic pathway, it is possible to administer HHT at low concentrations in combination with SAHA as an effective therapeutic approach for the treatment of AML.

Pair Name	Hypericin, Gemcitabine
Phytochemical	Hypericin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	We demonstrated that Gem combined HY-PDT could inhibit the proliferation of Capan-2 cells and induce cell apoptosis. HY-PDT combined with Gem had a great potential on pancreatic cancer treatment clinically.

Pair Name	Isoliquiritigenin, Docosahexaenoic acid
Phytochemical	Isoliquiritigenin
Drug	Docosahexaenoic acid
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Excessive ROS-induced JNK activation and cytochrome c release from mitochondria played a key role in the synergistic anticancer activity of CRC cells by cotreating with DHA and ISL.

Pair Name	Isorhamnetin, Chloroquine
Phytochemical	Isorhamnetin
Drug	Chloroquine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Our study highlights the critical role of ROS-mediating CaMKII/Drp1 signaling in the regulation of mitochondrial fission and apoptosis induced by combination of CQ/IH. These findings also suggest that IH could potentially be further developed as a novel chemotherapeutic agent. Furthermore, a combination of IH with classic autophagy/mitophagy inhibitor could represent a novel therapeutic strategy for the treatment of TNBC.

Pair Name	Juglone, Indomethacin
Phytochemical	Juglone
Drug	Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	A combination of both was shown to be more effective, suggesting that juglone may be considered for therapeutic intervention of colon cancer.

Pair Name	Luteolin, Oxaliplatin
Phytochemical	Luteolin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Luteolin can induce p53-mediated apoptosis regardless of oxaliplatin treatment and may eliminate oxaliplatin-resistant p53-null colorectal cells

Pair Name	Luteolin, Oxaliplatin
Phytochemical	Luteolin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Luteolin Suppresses the Proliferation of Gastric Cancer Cells and Acts in Synergy with Oxaliplatin through the Cyt c/caspase pathway

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Morin, Auranofin
Phytochemical	Morin
Drug	Auranofin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	This study provides evidence that morin can enhance the anticancer activity of AF in Hep3B human hepatocellular carcinoma cells, indicating that its combination could be an alternative treatment strategy for the hepatocellular carcinoma.

Pair Name	Phenethyl isothiocyanate, Irinotecan
Phytochemical	Phenethyl isothiocyanate
Drug	Irinotecan
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.

Pair Name	Platycodin D, Venetoclax
Phytochemical	Platycodin D
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Cytochrome c		Expression
Result	Platycodin D may be a potent therapeutic candidate for the treatment of AML

Pair Name	Pristimerin, Sorafenib
Phytochemical	Pristimerin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway

Pair Name	Propyl gallate, Cisplatin
Phytochemical	Propyl gallate
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Our data provide the potential application of PG in combination chemotherapy to enhance drug sensitivity in lung cancer by targeting HO-1.

Pair Name	Quercetin, Oxaliplatin
Phytochemical	Quercetin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	These findings suggest that the depletion of intracellular glutathione by quercetin and sulforaphane could strengthen the anti-cancer efficacy of oxaliplatin.

Pair Name	RA-V, Doxorubicin
Phytochemical	RA-V
Drug	Doxorubicin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	This work represents a versatile strategy for precise combination therapy against resistant tumor with spatiotemporal control, and provides a potential tool for Cyt c-related apoptotic studies.

Pair Name	Sulforaphene, Carboplatin
Phytochemical	Sulforaphene
Drug	Carboplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	This study demonstrates that the duel character of this combination therapy may be an effective replacement for conventional therapy alone against NSCLC.

Pair Name	Sulforaphene, Cisplatin
Phytochemical	Sulforaphene
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian Cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	SFE synergistically inhibited proliferation and induced apoptosis of SKOV3 and SNU8 cells in combination with cisplatin by activating multiple apoptotic pathways. Therefore, we suggest sulforaphene as a chemo-enhancing adjuvant to improve the efficacy of cisplatin in ovarian cancer treatment.

Pair Name	Sulforaphene, Photodynamic therapy
Phytochemical	Sulforaphene
Drug	Photodynamic therapy
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	This study could be useful in the improvement of therapies for human cervical and other types of cancers.

Pair Name	Tannic acid, Cisplatin
Phytochemical	Tannic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer.

Pair Name	Tea polyphenol, Paclitaxel
Phytochemical	Tea polyphenol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Our results showed that the combination of green tea and PTX could be more potent than the individual drug to induce cytotoxicity and apoptosis in ovarian cancer cells.

Pair Name	Tetrandrine, Sorafenib
Phytochemical	Tetrandrine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	The antitumour activity of sorafenib plus tetrandrine may be attributed to the induction of the intrinsic apoptosis pathway through ROS/Akt signaling. This finding provides a novel approach that may broaden the clinical application of sorafenib.

Pair Name	2,3,5,6-Tetramethylpyrazine, Cisplatin
Phytochemical	2,3,5,6-Tetramethylpyrazine
Drug	Cisplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	A series of ligustrazine-derived chalcones-modified platinum(IV) complexes were synthesized and evaluated for their anti-proliferative potency and generated an optimal platinum(IV) complex 16a. The above-described results indicated that 16a obtained different anti-cancer mechanisms of CDDP, which could initiate mitochondria-dependent apoptosis and xCT-GPX4 axial-mediated ferroptosis in PANC-1/CDDP cells.

Pair Name	Cepharanthine, Cisplatin
Phytochemical	Cepharanthine
Drug	Cisplatin
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals

Pair Name	Platycodin D, Histone deacetylase inhibitor
Phytochemical	Platycodin D
Drug	Histone deacetylase inhibitor
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cytochrome c		Expression
Result	Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation