calycosin-7-O-beta-D-glucoside, ononin
| Name | Ononin | ||
| PubChem CID | 442813 | ||
| Molecular Weight | 430.4g/mol | ||
| Synonyms |
calycosin-7-O-beta-D-glucoside, ononin |
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| Formula | C₂₂H₂₂O₉ | ||
| SMILES | COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O | ||
| InChI | 1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1 | ||
| InChIKey | MGJLSBDCWOSMHL-MIUGBVLSSA-N | ||
| CAS Number | 486-62-4 | ||
| ChEMBL ID | CHEMBL465980 | ||
| ChEBI ID | CHEBI:7775 | ||
| Herb ID | HBIN038168 | ||
| KEGG ID | C10509 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | HuangQi | ||
| Use Part | Root | ||
| Habitat | NeiMengGu, ShanXi, GanSu, HeiLongJiang | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Astragalus
-->Species: Astragalus membranaceus
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| Chineses Pinyin | ShenJinCao | ||
| Use Part | Lycopodium Japonicum Thunb | ||
| Habitat | HuBei | ||
| Flavor | Mildly bitter, Pungent | ||
| Meridian Tropism | Liver, Spleen, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lycopodiales
-->Family: Lycopodiaceae
-->Genus: Lycopodium
-->Species: Lycopodium japonicum
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| Chineses Pinyin | PuDiWuGong | ||
| Use Part | Whole Plant | ||
| Habitat | ZheJiang, FuJian, TaiWan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver, Spleen, Kidney | ||
| Chineses Pinyin | MengGuHuangQi | ||
| Use Part | Root | ||
| Habitat | HeiLongJiang, JiLin, NeiMengGu, HeBei, ShanXi, XiZang | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Magnoliopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Astragalus
-->Species: Astragalus membranaceus
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| Pair Name | Ononin, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | PIK3CB | KEGG ID N.A. |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Down-regulation | Expression | MTOR | hsa2475 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Expression | CDH2 | hsa1000 | |
| Down-regulation | Expression | MMP2 | hsa4313 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| In Vivo Model | A549 cells (5×10⁹/mL) were inserted subcutaneously into each mouse's flank. | |||
| Result | Our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin. | |||
