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5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one, tricetin

No.	Title	Href
1	Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1. Expert Opin Ther Targets. 2015;19(10):1293-306. doi: 10.1517/14728222.2015.1075509.	`Click`

No.

Title

Href

Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1. Expert Opin Ther Targets. 2015;19(10):1293-306. doi: 10.1517/14728222.2015.1075509.

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Name	Tricetin
PubChem CID	5281701
Molecular Weight	302.23g/mol
Synonyms	5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one, tricetin
Formula	C₁₅H₁₀O₇
SMILES	C1=C(C=C(C(=C1O)O)O)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
InChI	1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H
InChIKey	ARSRJFRKVXALTF-UHFFFAOYSA-N
CAS Number	520-31-0
ChEMBL ID	CHEMBL247484
ChEBI ID	CHEBI:507499
Drug Bank ID	DB08230
KEGG ID	C10192
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	ShiLiuPi
Use Part	Pericarp
Habitat	China
Flavor	Sour, Astringent
Meridian Tropism	Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Myrtales 　　　　-->Family: Lythraceae 　　　　　-->Genus: Punica 　　　　　　-->Species: Punica granatum

Chineses Pinyin	BaiGuoYe
Use Part	Leaf
Habitat	China
Flavor	Bitter, Sweet, Astringent
Meridian Tropism	Heart, Lung, Spleen

Chineses Pinyin	HuaHuangQi
Use Part	Seed
Habitat	LiaoNing, JiLin, HeiLongJiang, NeiMengGu, HeBei, ShanXi
Flavor	Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Astragalus 　　　　　　-->Species: Astragalus chinensis

Chineses Pinyin	YanMai
Habitat	NeiMengGu, HeBei, JiLin, ShanXi, Shaanxi, QingHai, GanSu, YunNan, GuiZhou, SiChuan, XiZang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Poales 　　　　-->Family: Poaceae 　　　　　-->Genus: Avena 　　　　　　-->Species: Avena sativa

Pair Name	Tricetin, ERK inhibitor
Partner Name	ERK inhibitor
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Down-regulation	Expression	MMP2	hsa4313
Gene Regulation	Down-regulation	Expression	SP1	hsa6667
Result	SP-1 is an important target of tricetin for suppressing MMP-2-mediated cell motility in GBM cells, and a combination of tricetin and an ERK inhibitor may be a good strategy for preventing GBM invasion.