InterPAD - DETAILS

8 Methoxypsoralen, 8 MOP, 8-Methoxypsoralen, 8-MOP, 8MOP, Ammoidin, Deltasoralen, Dermox, Geroxalen, Méladinine, Meladinina, Meladinine, Meloxine, Methoxa Dome, Methoxa-Dome, Methoxsalen, Oxsoralen, Oxsoralen Ultra, Oxsoralen-Ultra, Puvalen, Ultramop, Xanthotoxin

No.	Title	Href
1	Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells. Int J Mol Sci. 2021 Jan 7;22(2):537. doi: 10.3390/ijms22020537.	`Click`
2	4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells. Sci Rep. 2023 Jun 8;13(1):9356. doi: 10.1038/s41598-023-35045-3.	`Click`

No.

Title

Href

Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells. Int J Mol Sci. 2021 Jan 7;22(2):537. doi: 10.3390/ijms22020537.

Click

4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells. Sci Rep. 2023 Jun 8;13(1):9356. doi: 10.1038/s41598-023-35045-3.

Click

Name	Methoxsalen
PubChem CID	4114
Molecular Weight	216.19g/mol
Synonyms	8 Methoxypsoralen, 8 MOP, 8-Methoxypsoralen, 8-MOP, 8MOP, Ammoidin, Deltasoralen, Dermox, Geroxalen, Méladinine, Meladinina, Meladinine, Meloxine, Methoxa Dome, Methoxa-Dome, Methoxsalen, Oxsoralen, Oxsoralen Ultra, Oxsoralen-Ultra, Puvalen, Ultramop, Xanthotoxin
Formula	C₁₂H₈O₄
SMILES	COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
InChI	1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChIKey	QXKHYNVANLEOEG-UHFFFAOYSA-N
CAS Number	298-81-7
ChEMBL ID	CHEMBL416
ChEBI ID	CHEBI:18358
Drug Bank ID	DB00553
KEGG ID	C01864
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BuGuZhi
Use Part	Fruit
Flavor	Pungent; Bitter
Meridian Tropism	Kidney; Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Cullen 　　　　　　-->Species: Cullen corylifolium

Pair Name	Methoxsalen, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
In Vitro Model	FM55p	Cutaneous melanoma	Homo sapiens (Human)	CVCL_C591
In Vitro Model	FM55M2	Cutaneous melanoma	Homo sapiens (Human)	CVCL_C590
Result	Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells

Pair Name	Methoxsalen, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Inhibition-->Cell proliferation
Gene Regulation	Down-regulation	Expression	MMP2	hsa4313
In Vitro Model	U-251MG	Astrocytoma	Homo sapiens (Human)	CVCL_0021
In Vitro Model	LN-229	Glioblastoma	Homo sapiens (Human)	CVCL_0393
Result	We showed a marked antitumor effect of 4MU on GBM cells alone and in combination with chemotherapy and proved, for the first time, the effect of 4MU on TMZ-resistant models, demonstrating that 4MU would be a potential therapeutic alternative for improving GBM therapy even on TMZ-refractory patients.