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protopanaxatriol, protopanaxatriol, (3beta,6alpha,12beta,20R)-isomer

No.	Title	Href
1	Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. J Exp Clin Cancer Res. 2019 Mar 15;38(1):129. doi: 10.1186/s13046-019-1120-4.	`Click`

No.

Title

Href

Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. J Exp Clin Cancer Res. 2019 Mar 15;38(1):129. doi: 10.1186/s13046-019-1120-4.

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Name	(20S)-Protopanaxatriol
PubChem CID	11468733
Molecular Weight	476.7g/mol
Synonyms	protopanaxatriol, protopanaxatriol, (3beta,6alpha,12beta,20R)-isomer
Formula	C₃₀H₅₂O₄
SMILES	CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C
InChI	1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28+,29+,30-/m0/s1
InChIKey	SHCBCKBYTHZQGZ-CJPZEJHVSA-N
CAS Number	34080-08-5
ChEMBL ID	CHEMBL255683
ChEBI ID	CHEBI:75951
KEGG ID	C20716
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	SanQi
Use Part	Root
Habitat	YunNan, GuangXi
Flavor	Sweet, Mildly bitter
Meridian Tropism	Liver, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Araliaceae 　　　　　-->Genus: Panax 　　　　　　-->Species: Panax notoginseng

Chineses Pinyin	RenShen
Use Part	Root
Habitat	JiLin, LiaoNing, HeiLongJiang
Flavor	Sweet; Slightly Bitter
Meridian Tropism	Spleen; Lung; Heart; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Araliaceae 　　　　　-->Genus: Panax 　　　　　　-->Species: Panax ginseng

Pair Name	(20S)-Protopanaxatriol, EGFR-TKI
Partner Name	EGFR-TKI
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Lipid accumulation
Gene Regulation	Down-regulation	Phosphorylation	EGFR	hsa1956
Gene Regulation	Down-regulation	Expression	SCD	hsa6319
In Vitro Model	HCC827	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_2063
	PC-9	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_B260
	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
	HCC827-GR-high1	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_S703
In Vivo Model	Approximately 1×10⁷ H1975-luc cells were subcutaneously injected into the right hind limbs of mice.
Result	Our findings uncover a link between lipid metabolic reprogramming and EGFR-TKI resistance, confirmed that combination target both EGFR and abnormal lipid metabolism maybe a promising therapy for EGFR-TKI resistance and highlighting the possibility of monitoring lipid accumulation in tumors for predicting drug resistance.