deoxybouvardin, RA V, RA-V
| Name | RA-V | ||
| PubChem CID | 13361282 | ||
| Molecular Weight | 756.8g/mol | ||
| Synonyms |
deoxybouvardin, RA V, RA-V |
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| Formula | C₄₀H₄₈N₆O₉ | ||
| SMILES | CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C2CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC(C(=O)N1)N(C2=O)C)O)C)C)CC5=CC=C(C=C5)OC)C)C | ||
| InChI | 1S/C40H48N6O9/c1-22-35(48)42-23(2)38(51)44(4)30(18-25-8-13-28(54-7)14-9-25)37(50)43-24(3)39(52)46(6)32-19-26-10-15-29(16-11-26)55-34-21-27(12-17-33(34)47)20-31(36(49)41-22)45(5)40(32)53/h8-17,21-24,30-32,47H,18-20H2,1-7H3,(H,41,49)(H,42,48)(H,43,50)/t22-,23+,24+,30+,31+,32+/m1/s1 | ||
| InChIKey | VXVGFMUNENQGFW-LZQLRFBTSA-N | ||
| ChEMBL ID | CHEMBL404613 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | QianCao | ||
| Use Part | Root | ||
| Habitat | Shaanxi, HeBei, ShanDong, HeNan, AnHui | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Rubia
-->Species: Rubia cordifolia
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| Pair Name | RA-V, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C77] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CYCS | hsa54205 |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| In Vivo Model | The HeLa cells (5×10⁶ cells) were transplanted subcutaneously into the 8-week female BALB/c nude mice by using a stereotactic fixation device with mouse adaptor. | |||
| Result | This work represents a versatile strategy for precise combination therapy against resistant tumor with spatiotemporal control, and provides a potential tool for Cyt c-related apoptotic studies. | |||
