hyperin, hyperoside, quercetin galactoside, quercetin-3-O-galactoside
| Name | Hyperoside | ||
| PubChem CID | 5281643 | ||
| Molecular Weight | 464.4g/mol | ||
| Synonyms |
hyperin, hyperoside, quercetin galactoside, quercetin-3-O-galactoside |
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| Formula | C₂₁H₂₀O₁₂ | ||
| SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O | ||
| InChI | 1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1 | ||
| InChIKey | OVSQVDMCBVZWGM-DTGCRPNFSA-N | ||
| CAS Number | 482-36-0 | ||
| ChEMBL ID | CHEMBL251254 | ||
| ChEBI ID | CHEBI:67486 | ||
| Herb ID | HBIN029837 | ||
| Drug Bank ID | DB16403 | ||
| KEGG ID | C10073 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | HeYe | ||
| Use Part | Leaf | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nelumbonaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Chineses Pinyin | JinSiTao | ||
| Use Part | Root; Stem; Leaf; Flowers; Fruit | ||
| Flavor | Pungent | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum monogynum
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| Pair Name | Hyperoside, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Expression | IL6 | hsa3569 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Activity | TLR4 | hsa7099 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| HCC1806 | Breast squamous cell carcinoma, acantholytic variant | Homo sapiens (Human) | CVCL_1258 | |
| Result | Hyperoside may elevate breast cancer cell sensitivity to paclitaxel by blocking TLR4 activation-mediated pro-inflammatory and pro-survival approaches, thereby endorsing its usefulness as a promising therapeutic combination to overcome chemosensitivity in breast cancer. | |||
