InterPAD - DETAILS

3-methyladenine, 5142-23-4, 3-Methyl-3H-purin-6-amine, 6-Amino-3-methylpurine, 3-MA, 3H-Purin-6-amine, 3-methyl-, 3-Methyl-3H-adenine, 3-methylpurin-6-amine, ADENINE, 3-METHYL-, NSC 66389, C6H7N5, 3-methyl adenine, MFCD00010531, CHEBI:38635, DR88TV7SNU, 3-METHYL-3H-PURIN-6-YLAMINE, 3-Methyladenine (3-MA), Autophagy Inhibitor, 3-MA, 3,9-dihydro-3-methyl-6H-Purin-6-imine, 60192-57-6, 3899G64TKW, 3-Methyladenine autophagy inhibitor, NSC-66389, Purine, 3,6-dihydro-6-imino-3-methyl-, 6H-Purin-6-imine, 3,7-dihydro-3-methyl-, 6H-Purin-6-imine, 3,9-dihydro-3-methyl-, n3-methyladenine, 3-MA nucleobase, N(3)-methyladenine, EINECS 225-908-6, BRN 0146087, 3-methyl-7H-purin-6-imine, 3-methyl-Adenine, 3-Methyladenine?, NSC66389, 1p7m, 4ai5, UNII-DR88TV7SNU, NCIOpen2_000270, purine, 6-amino-3-methyl-, SCHEMBL48369, 5-26-17-00151 (Beilstein Handbook Reference), MLS006010995, SCHEMBL254058, UNII-3899G64TKW, METHYLADENINE, N(3)-, CHEMBL292268, 3-METHYL-6-AMINOPURINE, CHEMBL4303725, SCHEMBL15764619, 3-Methyl-3H-purin-6-amine #, DTXSID80199406, EX-A130, FSASIHFSFGAIJM-UHFFFAOYSA-N, ZPBYVFQJHWLTFB-UHFFFAOYSA-N, Bio1_000422, Bio1_000911, Bio1_001400, DTXSID901346127, GLXC-04639, HMS3656P04, AMY11868, BCP02452, 3-Methyladenine, autophagy inhibitor, BDBM50488841, HB2267, s2767, AKOS003382321, AKOS006228458, CCG-206388, CS-5207, DB04104, NCGC00345447-02, AC-28818, AS-19224, HY-19312, PD019337, SMR002530641, SY026559, DB-051961, A7582, FT-0635560, FT-0671432, M2518, NS00005696, SW220216-1, 3-methyl-3H-purin-6-amine (ACD/Name 4.0), C00913, 3-methyl-3H-purin-6-ylamine (ACD/Name 4.0), 3-MA , NSC 66389, J-640198, J-800199, W-202935, BRD-K81647657-001-01-9, Q27094948, InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H

No.	Title	Href
1	The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells. Food Funct. 2014 Aug;5(8):1856-65. doi: 10.1039/c4fo00145a.	`Click`

No.

Title

Href

The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells. Food Funct. 2014 Aug;5(8):1856-65. doi: 10.1039/c4fo00145a.

Click

Name	3-methyladenine
PubChem CID	135398661
Molecular Weight	149.15g/mol
Synonyms	3-methyladenine, 5142-23-4, 3-Methyl-3H-purin-6-amine, 6-Amino-3-methylpurine, 3-MA, 3H-Purin-6-amine, 3-methyl-, 3-Methyl-3H-adenine, 3-methylpurin-6-amine, ADENINE, 3-METHYL-, NSC 66389, C6H7N5, 3-methyl adenine, MFCD00010531, CHEBI:38635, DR88TV7SNU, 3-METHYL-3H-PURIN-6-YLAMINE, 3-Methyladenine (3-MA), Autophagy Inhibitor, 3-MA, 3,9-dihydro-3-methyl-6H-Purin-6-imine, 60192-57-6, 3899G64TKW, 3-Methyladenine autophagy inhibitor, NSC-66389, Purine, 3,6-dihydro-6-imino-3-methyl-, 6H-Purin-6-imine, 3,7-dihydro-3-methyl-, 6H-Purin-6-imine, 3,9-dihydro-3-methyl-, n3-methyladenine, 3-MA nucleobase, N(3)-methyladenine, EINECS 225-908-6, BRN 0146087, 3-methyl-7H-purin-6-imine, 3-methyl-Adenine, 3-Methyladenine?, NSC66389, 1p7m, 4ai5, UNII-DR88TV7SNU, NCIOpen2_000270, purine, 6-amino-3-methyl-, SCHEMBL48369, 5-26-17-00151 (Beilstein Handbook Reference), MLS006010995, SCHEMBL254058, UNII-3899G64TKW, METHYLADENINE, N(3)-, CHEMBL292268, 3-METHYL-6-AMINOPURINE, CHEMBL4303725, SCHEMBL15764619, 3-Methyl-3H-purin-6-amine #, DTXSID80199406, EX-A130, FSASIHFSFGAIJM-UHFFFAOYSA-N, ZPBYVFQJHWLTFB-UHFFFAOYSA-N, Bio1_000422, Bio1_000911, Bio1_001400, DTXSID901346127, GLXC-04639, HMS3656P04, AMY11868, BCP02452, 3-Methyladenine, autophagy inhibitor, BDBM50488841, HB2267, s2767, AKOS003382321, AKOS006228458, CCG-206388, CS-5207, DB04104, NCGC00345447-02, AC-28818, AS-19224, HY-19312, PD019337, SMR002530641, SY026559, DB-051961, A7582, FT-0635560, FT-0671432, M2518, NS00005696, SW220216-1, 3-methyl-3H-purin-6-amine (ACD/Name 4.0), C00913, 3-methyl-3H-purin-6-ylamine (ACD/Name 4.0), 3-MA , NSC 66389, J-640198, J-800199, W-202935, BRD-K81647657-001-01-9, Q27094948, InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H
Drug Type	Small molecule
Formula	C₆H₇N₅
SMILES	CN1C=NC(=N)C2=C1N=CN2
InChI	1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
InChIKey	ZPBYVFQJHWLTFB-UHFFFAOYSA-N
CAS Number	5142-23-4
ChEMBL ID	CHEMBL292268
ChEBI ID	CHEBI:38635
Drug Bank ID	DB04104
KEGG ID	C00913
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Pterostilbene, 3-methyladenine
Partner Name	Pterostilbene
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	BT-549	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_1092
Result	These data showed that Fas signaling and autophagy accelerated the aggressiveness of TNBC. Inhibition of autophagy or Fas signaling may provide novel targets for TNBC therapy.