InterPAD - DETAILS

1,3,6,7-tetrahydroxy-2,5-bis(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2- butenyl)-9H-xanthen-9-one, 7-O-methyl-4-desprenylcostatin, 7-O-methyl-gamma-mangostin, alfa-mangostin, alpha-mangosten, alpha-mangostin, gamma-mangostin, mangostin

No.	Title	Href
1	The Effect of α-Mangostin and Cisplatin on Ovarian Cancer Cells and the Microenvironment. Biomedicines. 2022 May 11;10(5):1116. doi: 10.3390/biomedicines10051116.	`Click`
2	Synergistic effects of α-Mangostin and sorafenib in hepatocellular carcinoma: New insights into α-mangostin cytotoxicity. Biochem Biophys Res Commun. 2021 Jun 18;558:14-21. doi: 10.1016/j.bbrc.2021.04.047.	`Click`
3	α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades. J Cell Mol Med. 2020 Jan;24(1):760-771. doi: 10.1111/jcmm.14785.	`Click`
4	Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. Oncol Rep. 2017 Dec;38(6):3439-3446. doi: 10.3892/or.2017.6030.	`Click`
5	Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217.	`Click`
6	Synergic Effect of α-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model. Oxid Med Cell Longev. 2016;2016:7981397. doi:10.1155/2016/7981397	`Click`

No.

Title

Href

The Effect of α-Mangostin and Cisplatin on Ovarian Cancer Cells and the Microenvironment. Biomedicines. 2022 May 11;10(5):1116. doi: 10.3390/biomedicines10051116.

Click

Synergistic effects of α-Mangostin and sorafenib in hepatocellular carcinoma: New insights into α-mangostin cytotoxicity. Biochem Biophys Res Commun. 2021 Jun 18;558:14-21. doi: 10.1016/j.bbrc.2021.04.047.

Click

α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades. J Cell Mol Med. 2020 Jan;24(1):760-771. doi: 10.1111/jcmm.14785.

Click

Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. Oncol Rep. 2017 Dec;38(6):3439-3446. doi: 10.3892/or.2017.6030.

Click

Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217.

Click

Synergic Effect of α-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model. Oxid Med Cell Longev. 2016;2016:7981397. doi:10.1155/2016/7981397

Click

Name	alpha-Mangostin
PubChem CID	5281650
Molecular Weight	410.5g/mol
Synonyms	1,3,6,7-tetrahydroxy-2,5-bis(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2- butenyl)-9H-xanthen-9-one, 7-O-methyl-4-desprenylcostatin, 7-O-methyl-gamma-mangostin, alfa-mangostin, alpha-mangosten, alpha-mangostin, gamma-mangostin, mangostin
Formula	C₂₄H₂₆O₆
SMILES	CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C
InChI	1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey	GNRIZKKCNOBBMO-UHFFFAOYSA-N
CAS Number	6147-11-1
ChEMBL ID	CHEMBL323197
ChEBI ID	CHEBI:67547
Drug Bank ID	DB14371
KEGG ID	C10080
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	ShanZhu
Use Part	Bark or fruit
Species	>Kingdom: Viridiplantae 　-->Phylum: Tracheophyta 　　-->Class: Magnoliopsida 　　　-->Order: Malpighiales 　　　　-->Family: Clusiaceae 　　　　　-->Genus: Garcinic 　　　　　　-->Species: Garcinic mangostana

Pair Name	alpha-Mangostin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Microenvironment
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	TOV-21G	Ovarian clear cell adenocarcinoma	Homo sapiens (Human)	CVCL_3613
	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	It is important to note that the cargo carried by exosomes released from drug-treated cells may be significantly different.

Pair Name	alpha-Mangostin, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	LRRC8A	hsa56262
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Expression	PRKAA1	hsa5562
	Up-regulation	Expression	RNF181	hsa51255
In Vivo Model	Hep3B and MHCC97L cells (5×10⁶) were injected subcutaneously into the right flank of the male BALB/c nude mice (4–6 weeks old).
Result	Our results highlight the synergistic effect of the combination of sorafenib and α-Mangostin, which indicates a potential treatment for advanced HCC for patients that are not sensitive to sorafenib therapy.

Pair Name	alpha-Mangostin, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C13]	Gallbladder cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ACACA	hsa31
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	FASN	hsa2194
	Down-regulation	Expression	PCNA	hsa5111
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Down-regulation	Expression	SREBF1	hsa6720
In Vitro Model	GBC-SD	Gallbladder carcinoma	Homo sapiens (Human)	CVCL_6903
In Vitro Model	NOZ	Gallbladder carcinoma	Homo sapiens (Human)	CVCL_3079
Result	α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades.

Pair Name	alpha-Mangostin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B66.0]	Oral squamous cell carcinoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in the S/G2/M phase
Gene Regulation	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP7	hsa840
	Up-regulation	Activity	CASP9	hsa842
	Up-regulation	Expression	MYC	hsa4609
In Vitro Model	HSC-4	Tongue squamous cell carcinoma	Homo sapiens (Human)	CVCL_1289
In Vitro Model	SAS	Tongue squamous cell carcinoma	Homo sapiens (Human)	CVCL_1675
Result	Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway

Pair Name	alpha-Mangostin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
In Vivo Model	All mice were subcutaneously inoculated in the back with 5 × 106 HeLa (cervical cancer) cells. Once the tumor reached about 150 mm3, mice were divided into the following four groups: (1) control, orally administrated 0.5% carboxymethyl-cellulose, (2) the α-M treatment, was treated orally with 12.5 mg/Kg (suspended in 0.5% carboxymethyl-cellulose), (3) the CDDP treatment, intraperitoneally injected with CDDP (3 mg/Kg), and (4) the CDDP+α-M treatment, administered at the doses and by the routes aforementioned for these compounds.
Result	This effect was accompanied by increased apoptosis and ROS production by HeLa cervical cancer cells, as well as an arrest in the cell cycle. These results suggest that α-M may be useful as a neoadjuvant agent in cervical cancer therapy.