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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Low molecular weight phosphotyrosine protein phosphatase
UniProt ID PPAC_HUMAN
Gene Name ACP1
Gene ID 52
Synonyms
ACP1, HAAP, LMW-PTP, LMWPTP
Sequence
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
Pathway Map MAP LINK
KEGG ID hsa52
Pfam PF01451
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 117
Pair Name Morin, Fludarabine
Phytochemical Morin
Drug Fludarabine
Disease Info [ICD-11: 2A82] Chronic lymphocytic leukemia Investigative
Regulate Info Down-regulation Low molecular weight phosphotyrosine protein phosphatase Expression
Result Morin treatment in CLL-derived Mec-1 cell line synergizes with conventional anticancer drugs currently used in CLL therapy by affecting leukemic cell viability and trafficking.
03. Reference
No. Title Href
1 LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy. Cancer Cell Int. 2019 Mar 21;19:67. doi: 10.1186/s12935-019-0786-1. Click
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