| Name | Catalase | ||
| UniProt ID | CATA_HUMAN | ||
| Gene Name | CAT | ||
| Gene ID | 847 | ||
| Synonyms |
CAT
|
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| Sequence |
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.1.1.1; 1.A.1.10.13; 1.A.1.10.19; 1.A.1.10.3; 1.A.1.10.4 | ||
| KEGG ID | hsa847 | ||
| TTD ID | T01597 | ||
| Pfam | PF00199; PF06628 | ||
| Pair Name | Chrysin, Paclitaxel | |||
| Phytochemical Name | Chrysin | |||
| Anticancer drug Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Regulate Info | Down-regulation | Catalase | Expression | |
| Result | CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity. | |||
| Pair Name | Bufalin, Sorafenib | |||
| Phytochemical | Bufalin | |||
| Drug | Sorafenib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Regulate Info | Down-regulation | Catalase | Expression | |
| Result | Sorafenib in combination with bufalin shows more potent cytotoxic effects and cell apoptosis than sorafenib or bufalin treatment alone in NCI-H292 cells. The combined treatment significantly enhanced apoptotic cell death in NCI-H292 lung cancer cells by activating ROS-, mitochondria-, and caspase-signaling pathways in vitro. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis. Life Sci. 2023 Nov 1;332:122096. doi: 10.1016/j.lfs.2023.122096. | Click |
| 2 | Combination Treatment of Sorafenib and Bufalin Induces Apoptosis in NCI-H292 Human Lung Cancer Cells In Vitro. In Vivo. 2022 Mar-Apr;36(2):582-595. doi: 10.21873/invivo.12741. | Click |
