| Name | Superoxide dismutase | ||
| UniProt ID | SODC_HUMAN | ||
| Gene Name | SOD1 | ||
| Gene ID | 6647 | ||
| Synonyms |
SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimer
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| Sequence |
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 2.A.36.4.3 | ||
| KEGG ID | hsa6647 | ||
| TTD ID | T29024 | ||
| Pfam | PF00080 | ||
| Pair Name | Amygdalin, Sorafenib | |||
| Phytochemical Name | Amygdalin | |||
| Anticancer drug Name | Sorafenib | |||
| Disease Info | [ICD-11: 2D91] | Ehrlich ascites carcinoma | Investigative | |
| Regulate Info | Up-regulation | Superoxide dismutase | Expression | |
| Result | Amy improved the antitumor effect of Sor and had a protective role on liver damage induced by EAC in mice. | |||
| Pair Name | Chrysin, Paclitaxel | |||
| Phytochemical Name | Chrysin | |||
| Anticancer drug Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Regulate Info | Down-regulation | Superoxide dismutase | Expression | |
| Result | CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity. | |||
| Pair Name | Usnic acid, Bleomycin | |||
| Phytochemical Name | Usnic acid | |||
| Anticancer drug Name | Bleomycin | |||
| Disease Info | [ICD-11: 2F94] | Ascitic tumor | Investigative | |
| Regulate Info | Down-regulation | Superoxide dismutase | Expression | |
| Result | Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin | |||
| Pair Name | Bufalin, Sorafenib | |||
| Phytochemical | Bufalin | |||
| Drug | Sorafenib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Regulate Info | Up-regulation | Superoxide dismutase | Expression | |
| Result | Sorafenib in combination with bufalin shows more potent cytotoxic effects and cell apoptosis than sorafenib or bufalin treatment alone in NCI-H292 cells. The combined treatment significantly enhanced apoptotic cell death in NCI-H292 lung cancer cells by activating ROS-, mitochondria-, and caspase-signaling pathways in vitro. | |||
| Pair Name | Embelin, TRAIL | |||
| Phytochemical | Embelin | |||
| Drug | TRAIL | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Regulate Info | Down-regulation | Superoxide dismutase | Expression | |
| Result | Embelin primes IBC cells for TRAIL-mediated apoptosis by its direct action on the anti-caspase activity of XIAP and by shifting the cellular redox balance toward oxidative stress–mediated apoptosis | |||
| No. | Title | Href |
|---|---|---|
| 1 | Amygdalin potentiates the anti-cancer effect of Sorafenib on Ehrlich ascites carcinoma and ameliorates the associated liver damage. Sci Rep. 2022 Apr 20;12(1):6494. doi: 10.1038/s41598-022-10517-0. | Click |
| 2 | Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis. Life Sci. 2023 Nov 1;332:122096. doi: 10.1016/j.lfs.2023.122096. | Click |
| 3 | Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. Int Immunopharmacol. 2017 May;46:146-155. doi: 10.1016/j.intimp.2017.03.004. | Click |
| 4 | Combination Treatment of Sorafenib and Bufalin Induces Apoptosis in NCI-H292 Human Lung Cancer Cells In Vitro. In Vivo. 2022 Mar-Apr;36(2):582-595. doi: 10.21873/invivo.12741. | Click |
| 5 | XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. Mol Cancer Ther. 2012;11(7):1518-1527. doi:10.1158/1535-7163.MCT-11-0787 | Click |
