Pair Name	Lupeol, Enzalutamide
Phytochemical Name	Lupeol
Anticancer drug Name	Enzalutamide
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Lupeol enhances the pharmacological efficacy of Enzalutamide and reduces the adverse effects. Thus, Lupeol could be a promising adjuvant for improving Enzalutamide-based treatment outcomes and warrant further research.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Amentoflavone may sensitize OS to sorafenib treatment by inducing intrinsic and extrinsic apoptosis and inhibiting ERK/NF-κB signaling transduction.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Our results demonstrated that amentoflavone significantly enhanced sorafenib-inhibited tumor growth and expression of ERK/AKT phosphorylation and anti-apoptotic proteins compared to single-agent treatment. Additionally, amentoflavone also triggered sorafenib-induced apoptosis through extrinsic and intrinsic apoptotic pathways.

Pair Name	Angelicin, TNF-related apoptosis inducing ligand
Phytochemical	Angelicin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C90.Z]	Renal carcinoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	This study provides evidence that angelicin might be a TRAIL sensitizer.

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A90]	Anaplastic large cell lymphoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Apigenin breaks TRAIL resistance in HTLV-1-associated ATL by transcriptional down-regulation of c-FLIP, a key inhibitor of death receptor signaling, and by up-regulation of TRAIL receptor 2 (TRAIL-R2)

Pair Name	Bakuchiol, TNF-related apoptosis inducing ligand
Phytochemical	Bakuchiol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	The collective results suggest that bakuchiol facilitates TRAIL-induced apoptosis in colon cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS/JNK pathway signals.

Pair Name	Cantharidin, TNF-related apoptosis inducing ligand
Phytochemical	Cantharidin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	The results of the present study revealed that cantharidin effectively sensitized cells to TRAIL‑mediated apoptosis and its effects are likely to be mediated by autophagy, the downregulation of c‑FLIP and the upregulation of DR‑5.

Pair Name	Casticin, TNF-related apoptosis inducing ligand
Phytochemical	Casticin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Casticin enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-ER stress-CHOP pathway.

Pair Name	Chrysin, Cisplatin
Phytochemical	Chrysin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	The combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through Down-regulation of cFLIP and Activity of Caspase.

Pair Name	Delta-Tocotrienol, Docetaxel
Phytochemical	Delta-Tocotrienol
Drug	Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	The ability of δ-TT to induce necroptotic cell death may represent a promising therapeutical approach to overcome DTX chemoresistance in PCa.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B6B]	Nasopharyngeal carcinoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	EGCG sensitizes NPC cells to TRAIL-mediated apoptosis via modulation of extrinsic and intrinsic apoptotic pathways and inhibition of NF-κB activation.

Pair Name	Icaritin, TNF-related apoptosis inducing ligand
Phytochemical	Icaritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	These data suggest that icaritin sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-κB-dependent c-FLIP expression, providing in vitro evidence supporting the notion that icaritin is a potential sensitizer of TRAIL in anticancer therapy against human GBM.

Pair Name	Irigenin, TNF-related apoptosis inducing ligand
Phytochemical	Irigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment.

Pair Name	Kaempferol, TNF-related apoptosis inducing ligand
Phytochemical	Kaempferol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	It is reasonable to conclude that sensitization of chronic leukemia cells to TRAIL by kaempferol in vitro should be considered as a way of focusing clinical attention on leukemia therapy.

Pair Name	Kurarinone, TNF-related apoptosis inducing ligand
Phytochemical	Kurarinone
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Plumbagin, rsTRAIL
Phytochemical	Plumbagin
Drug	rsTRAIL
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Our results suggest that both plumbagin and rsTRAIL could be used as a single agent or synergistical agents to induce apoptosis of leukemic Kasumi‑1 cells in vitro and in vivo.

Pair Name	Shikonin, TNF-related apoptosis inducing ligand
Phytochemical	Shikonin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	The results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.

Pair Name	Tectorigenin, Paclitaxel
Phytochemical	Tectorigenin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer.

Pair Name	Tubeimoside I, TNF-related apoptosis inducing ligand
Phytochemical	Tubeimoside I
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Our study revealed that STAMBPL1 is essential for c-FLIP stabilization, and that STAMBPL1 depletion enhances TRAIL-mediated apoptosis via c-FLIP downregulation.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	CASP8 and FADD-like apoptosis regulator		Expression
Result	Amentoflavone not only reversed sorafenib-induced anti-apoptotic protein levels but also enhanced sorafenib-induced pro-apoptotic protein expression in SK-Hep1R cells. In conclusion, amentoflavone may be used as a sorafenib sensitizer to enhance sorafenib-induced cytotoxicity and trigger sorafenib-induced apoptosis through extrinsic and intrinsic pathways in SK-Hep1R cells.