carnosic acid, salvin
| Name | Carnosic acid | ||
| PubChem CID | 65126 | ||
| Molecular Weight | 332.4g/mol | ||
| Synonyms |
carnosic acid, salvin |
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| Formula | C₂₀H₂₈O₄ | ||
| SMILES | CC(C)C1=C(C(=C2C(=C1)CCC3C2(CCCC3(C)C)C(=O)O)O)O | ||
| InChI | 1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1 | ||
| InChIKey | QRYRORQUOLYVBU-VBKZILBWSA-N | ||
| CAS Number | 3650-09-7 | ||
| ChEMBL ID | CHEMBL484853 | ||
| ChEBI ID | CHEBI:65585 | ||
| KEGG ID | C21818 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | YinChen | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Spleen, Stomach, Liver, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Artemisia
-->Species: Artemisia scoparia
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| Chineses Pinyin | MaBianCao | ||
| Use Part | Aerial Parts | ||
| Habitat | ShanXi, Shaanxi, GanSu, JiangSu, AnHui, ZheJiang, FuJian, JiangXi, HuBei, HuNan, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan, XinJiang, XiZang | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Verbenaceae
-->Genus: Verbena
-->Species: Verbena officinalis
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| Chineses Pinyin | MiDieXiang | ||
| Use Part | Whole herb | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia rosmarinus
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| Pair Name | Carnosic acid, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | ARG1 | hsa383 |
| Up-regulation | Expression | CD8A | hsa925 | |
| Up-regulation | Expression | FASLG | hsa356 | |
| Up-regulation | Expression | GZMB | hsa3002 | |
| Up-regulation | Expression | IFNG | hsa3458 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Up-regulation | Expression | PRF1 | hsa5551 | |
| In Vitro Model | A9 [Mouse Lewis lung carcinoma] | Malignant tumors of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_S007 |
| In Vivo Model | Mouse LLC (Lewis lung cancer) cells (5×10⁶ cells in 0.1 mL) were injected into the right flank of C57BL/6 mice. | |||
| Result | Our study proved that the functional suppression of MDSC by carnosic acid promoted the lethality of CD8 T cells, which contributed to the enhancement of anti-lung cancer effect of cisplatin. | |||
| Pair Name | Carnosic acid, Tamoxifen | |||
| Partner Name | Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAD | hsa572 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | TNFRSF10C | hsa8794 | |
| Up-regulation | Expression | TNFRSF10D | hsa8793 | |
| Up-regulation | Expression | TNFSF10 | hsa8743 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Up-regulation | Expression | TP73 | hsa7161 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| T-47D | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0553 | |
| In Vivo Model | 5×10⁵ MCF-7 cells were subcutaneously injected into the dorsal flanks of athymic nude mice. | |||
| Result | Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation. | |||
| Pair Name | Carnosic acid, Anti-PD-1 antibody | |||
| Partner Name | Anti-PD-1 antibody | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Down-regulation | Expression | CTNNB1 | hsa1499 |
| Down-regulation | Expression | GSK3B | hsa2932 | |
| Down-regulation | Expression | WNT3A | hsa89780 | |
| In Vitro Model | MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 |
| In Vivo Model | MHCC97H cells (4×10⁶ cells/site) were implanted subcutaneously into hip of four- to five-week-old male athymic nude mice. | |||
| Result | CA-NBF combined with anti-PD-1 have stronger immunomodulatory and anticancer effects without increasing biological toxicity. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma. Funct Integr Genomics. 2024 Jan 6;24(1):5. doi: 10.1007/s10142-024-01286-2. | Click |
| 2 | Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. Chin J Nat Med. 2018 Dec;16(12):907-915. doi: 10.1016/S1875-5364(18)30132-8. | Click |
| 3 | Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo. Biomed Pharmacother. 2017 May;89:827-837. doi: 10.1016/j.biopha.2017.01.084. | Click |
