Pair Name	Carnosic acid, Tamoxifen
Phytochemical	Carnosic acid
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor ligand superfamily member 10		Expression
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.

Pair Name	Homoharringtonine, Suberoylanilide hydroxamic acid (SAHA)
Phytochemical	Homoharringtonine
Drug	Suberoylanilide hydroxamic acid (SAHA)
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor ligand superfamily member 10		Expression
Result	The synergistic effect between HHT and SAHA was blocked partially using a specific anti‑TRAIL antibody. The combination therapy was also found to significantly inhibit the growth of leukemia xenografts in vivo with enhanced apoptosis. These results indicate that, by regulating the induction of TRAIL and activation of the TRAIL apoptotic pathway, it is possible to administer HHT at low concentrations in combination with SAHA as an effective therapeutic approach for the treatment of AML.

Pair Name	Platycodin D, Sorafenib
Phytochemical	Platycodin D
Drug	Sorafenib
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor ligand superfamily member 10		Expression
Result	The combination of Platycodin D and sorafenib may exert potent anti-cancer effects specifically via FOXO3a