Pair Name	Camptothecin, Camptosar
Phytochemical	Camptothecin
Drug	Camptosar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Granzyme B		Expression
Result	Camptothesome Potentiates PD-L1 Immune Checkpoint Blockade for Improved Metastatic Triple-Negative Breast Cancer Immunochemotherapy

Pair Name	Carnosic acid, Cisplatin
Phytochemical	Carnosic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Granzyme B		Expression
Result	Our study proved that the functional suppression of MDSC by carnosic acid promoted the lethality of CD8 T cells, which contributed to the enhancement of anti-lung cancer effect of cisplatin.

Pair Name	Vitamin C, Anti-PD-1 antibody
Phytochemical	Vitamin C
Drug	Anti-PD-1 antibody
Disease Info	[ICD-11: 2B33.5]	Lymphoma		Investigative
Regulate Info	Up-regulation	Granzyme B		Expression
Result	This study shows that AA treatment 1) increases immunogenicity of lymphoma cells; 2) enhances intratumoral infiltration of CD8+ T cells and macrophages; and 3) synergizes with anti-PD1 checkpoint inhibition in a syngeneic lymphoma mouse model via marked activation of cytotoxic cells (cytotoxic T cells and NK cells) and antigen presenting cells. The data provide a compelling rationale for testing combinations of high-dose AA and anti-PD1 agents in patients with aggressive B cell lymphoma and in preclinical models of other malignancies.