| Name | Betulin | ||
| PubChem CID | 72326 | ||
| Molecular Weight | 442.7g/mol | ||
| Synonyms |
(+)-betulin, (+)-betulin diacetate, 3,28-di-O-acetylbetulin, 3,28-diacetoxy-betulin, betulin, betulin diacetate, betuline, betulinic alcohol, betulinol, betulinol biacetate, betulinol diacetate, lup-20(29)-en-3 alpha, 28,30-triol, lup-20(29)-ene-3 beta,28-diol, lup-20(29)-ene-3,28-diol, 3,28-diacetate, (3 beta)-, lup-20(29)-ene-3alpha,28-diol |
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| Formula | C₃₀H₅₀O₂ | ||
| SMILES | CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO | ||
| InChI | 1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1 | ||
| InChIKey | FVWJYYTZTCVBKE-ROUWMTJPSA-N | ||
| CAS Number | 473-98-3 | ||
| ChEMBL ID | CHEMBL23236 | ||
| ChEBI ID | CHEBI:3086 | ||
| Herb ID | HBIN018374 | ||
| Drug Bank ID | DB16890 | ||
| KEGG ID | C08618 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | MiDieXiang | ||
| Use Part | Whole Grass | ||
| Habitat | Mediterranean | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Rosmarinus
-->Species: Rosmarinus officinalis
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| Chineses Pinyin | JieGeng | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Lung | ||
| Chineses Pinyin | MuXiang | ||
| Use Part | Root | ||
| Habitat | YunNan, SiChuan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Spleen, Stomach, Large intestine, Triple burner, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Aucklandia
-->Species: Aucklandia lappa
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| Chineses Pinyin | DaZao | ||
| Use Part | Ripe Fruit | ||
| Habitat | HeNan, HeBei, ShanDong | ||
| Flavor | Sweet | ||
| Meridian Tropism | Spleen, Stomach, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rhamnaceae
-->Genus: Ziziphus
-->Species: Ziziphus jujuba
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| Chineses Pinyin | CanDou | ||
| Use Part | Seed | ||
| Habitat | China | ||
| Flavor | Sweet, Mildly pungent | ||
| Meridian Tropism | Spleen, Stomach, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Vicia
-->Species: Vicia faba
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| Chineses Pinyin | HongHuaPi | ||
| Use Part | Bark | ||
| Habitat | YunNan, SiChuan, BeiJing, TianJin, ShanDong, JiangSu, ZheJiang, ShangHai, GuangDong, HaiNan, FuJian, TaiWan, Hongkong , HuBei, HeBei | ||
| Chineses Pinyin | HuTaoYe | ||
| Use Part | Leaf | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, NeiMengGu, HeBei, ShanXi, HeNan | ||
| Flavor | Sweet | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fagales
-->Family: Juglandaceae
-->Genus: Juglans
-->Species: Juglans mandshurica
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| Chineses Pinyin | JunQianZi | ||
| Use Part | Fruit | ||
| Habitat | LiaoNing, HeBei, ShanDong, Shaanxi, ShanXi, HuBei, HeNan, HuNan, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing | ||
| Flavor | Sweet, Astringent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ericales
-->Family: Ebenaceae
-->Genus: Diospyros
-->Species: Diospyros lotus
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| Chineses Pinyin | XuSuiZiJingZhongBaiZhi | ||
| Use Part | White Juice In Stem | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, HeBei, ShanXi, JiangSu, ZheJiang, FuJian, TaiWan, HeNan, HuNan, GuangXi, SiChuan, GuiZhou, YunNan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Euphorbiaceae
-->Genus: Euphorbia
-->Species: Euphorbia lathyris
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| Chineses Pinyin | CuYeXuanGouZi | ||
| Use Part | Root and leaf | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Rubus
-->Species: Rubus alceifolius
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| Pair Name | Betulin, Sorafenib | |||
| Partner Name | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Glycolysis | |||
| Gene Regulation | Up-regulation | Expression | SREBF1 | hsa6720 |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 | |
| SMMC-7721 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0534 | |
| BEL-7402 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_5492 | |
| MHCC97-L | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4973 | |
| MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 | |
| In Vivo Model | HCC cells were cultured, and the cells were injected subcutaneously into nude mice, antitumor agents were intragastrically administered 2–3 days after injection of HCC cells. | |||
| Result | Our data show that SREBP-1 inhibition facilitated the antitumor effects of Sorafenib on HCC cells and xenograft tumors. | |||
| Pair Name | Betulin, Arsenic oxide (As2O3) | |||
| Partner Name | Arsenic oxide (As2O3) | |||
| Disease Info | [ICD-11: 2D11] | Neuroblastoma | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Up-regulation | Expression | BAD | hsa572 |
| Up-regulation | Expression | BAK1 | hsa578 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BID | hsa637 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | SK-N-SH | Neuroblastoma | Homo sapiens (Human) | CVCL_0531 |
| Result | The novel combination of As2O3 plus betulin has the potential to serve as a practical anti-neuroblastoma drug. | |||
| Pair Name | Betulin, Gefitinib | |||
| Partner Name | Gefitinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Ferroptosis | |||
| Gene Regulation | Down-regulation | Expression | GSS | hsa2937 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 | |
| In Vivo Model | A xenograft model was constructed in vivo to investigate the role of the combination treatment of betulin and gefitinib in NSCLC tumor growth, it also inhibited the tumor growth of NSCLC in vivo. | |||
| Result | Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis | |||
| No. | Title | Href |
|---|---|---|
| 1 | SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity. Cell Death Dis. 2019 Sep 11;10(9):672. doi: 10.1038/s41419-019-1884-7. | Click |
| 2 | Involvement of Mitochondrial Damage and Oxidative Stress in Apoptosis Induced by Betulin Plus Arsenic Trioxide in Neuroblastoma Cells. Anticancer Res. 2023 Jun;43(6):2467-2476. doi: 10.21873/anticanres.16414. | Click |
| 3 | Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis. Neoplasma. 2022 May;69(3):648-656. doi: 10.4149/neo_2022_211103N1568. | Click |
