Pair Name	Rutin, Orlistat
Phytochemical Name	Rutin
Anticancer drug Name	Orlistat
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Fatty acid synthase		Expression
Result	Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions

Pair Name	Isoliquiritigenin, Docosahexaenoic acid
Phytochemical	Isoliquiritigenin
Drug	Docosahexaenoic acid
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	Excessive ROS-induced JNK activation and cytochrome c release from mitochondria played a key role in the synergistic anticancer activity of CRC cells by cotreating with DHA and ISL.

Pair Name	Silibinin, Paclitaxel
Phytochemical	Silibinin
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines

Pair Name	Oridonin, Cetuximab
Phytochemical	Oridonin
Drug	Cetuximab
Disease Info	[ICD-11: 2C23.Z]	Laryngeal cancer		Investigative
Regulate Info	Down-regulation	Fatty acid synthase		Expression
Result	Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway

Pair Name	Shikonin, 4-hydroxytamoxifen
Phytochemical	Shikonin
Drug	4-hydroxytamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	The combination of SK and 4-OHT shows highly efficient anticancer effects on breast cancer therapy. SK may be a promising candidate as an adjuvant to 4-OHT for breast cancer treatments, especially for ER- breast cancer.

Pair Name	Capsaicin, 3,3'-diindolylmethane
Phytochemical	Capsaicin
Drug	3,3'-diindolylmethane
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-κB, p53, and target genes associated with apoptosis.

Pair Name	Gossypol, Zoledronic acid
Phytochemical	Gossypol
Drug	Zoledronic acid
Disease Info	[ICD-11: 2C82.0]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins.

Pair Name	Gambogic Acid, Cisplatin
Phytochemical	Gambogic Acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-κB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy.

Pair Name	Gambogic Acid, Doxorubicin
Phytochemical	Gambogic Acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	These findings indicate that GA sensitizes lung cancer cells to ADM in vitro and in vivo, providing a rationale for the combined use of GA and ADM in lung cancer chemotherapy.

Pair Name	Lycopene, Eicosapentaenoic acid
Phytochemical	Lycopene
Drug	Eicosapentaenoic acid
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	Our novel findings suggest that lycopene and EPA synergistically inhibited the growth of human colon cancer HT-29 cells even at low concentration. The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway.

Pair Name	Phenethyl isothiocyanate, Irinotecan
Phytochemical	Phenethyl isothiocyanate
Drug	Irinotecan
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.

Pair Name	Gambogic acid, Cisplatin
Phytochemical	Gambogic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Fatty acid synthase		Expression
Result	Our results demonstrate that GA may be a new potent therapeutic agent useful for targeting human OS cells.