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Phytochemical Details

01. General Information

Name	Licochalcone B
PubChem CID	5318999
Molecular Weight	286.28g/mol
Synonyms	licochalcone B
Formula	C₁₆H₁₄O₅
SMILES	COC1=C(C=CC(=C1O)O)C=CC(=O)C2=CC=C(C=C2)O
InChI	1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
InChIKey	DRDRYGIIYOPBBZ-XBXARRHUSA-N
CAS Number	58749-23-8
ChEMBL ID	CHEMBL2437372
ChEBI ID	CHEBI:174733
Structure		Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Euphorbia helioscopia Cold

Chineses Pinyin	ZeQi
Use Part	Whole Grass
Habitat	China
Flavor	Pungent, Bitter
Meridian Tropism	Lung, Small intestine, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia helioscopia

(2) Glycyrrhiza uralensis Even

Chineses Pinyin	GanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu, GanSu, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

(3) Glycyrrhiza uralensis Even

Chineses Pinyin	ZhiGanCao
Use Part	Root, Rhizome Of Prepared Liauorice Root
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, XinJiang, ShanDong
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

(4) Prunus armeniaca Warm

Chineses Pinyin	KuXingRen
Use Part	Seed
Habitat	NeiMengGu, JiLin, LiaoNing, HeBei, ShanXi, Shaanxi
Flavor	Bitter
Meridian Tropism	Lung, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Prunus 　　　　　　-->Species: Prunus armeniaca

(5) Radix glycyrrhizae Even

Chineses Pinyin	GuangGuoGanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach

(6) Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle Warm

Chineses Pinyin	HuangGanCao
Use Part	Root, Rhizome
Habitat	XinJiang, NeiMengGu, NingXia, GanSu, ShanXi
Flavor	Sweet
Meridian Tropism	Heart, Lung, Stomach, Spleen

(7) Glycyrrhiza inflata Unknown

Chineses Pinyin	ZhangGuoGanCao
Use Part	Root, Rhizome
Habitat	NeiMengGu, GanSu, XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza inflata

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 129

Ref_1

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Phosphorylation	ATM	hsa472
	Up-regulation	Cleavage	CASP8	hsa841
	Down-regulation	Expression	CCNB1	hsa891
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Phosphorylation	CDK1	hsa983
	Down-regulation	Expression	CDK1	hsa983
	Up-regulation	Phosphorylation	CHEK2	hsa11200
	Up-regulation	Expression	DDIT3	hsa1649
	Down-regulation	Expression	EIF2AK3	hsa9451
	Up-regulation	Expression	H2AX	hsa3014
	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK3	hsa5595
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Phosphorylation	MAPK9	hsa5601
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

04. Reference

No.	Title	Href
1	Licochalcone B induces DNA damage, cell cycle arrest, apoptosis, and enhances TRAIL sensitivity in hepatocellular carcinoma cells. Chem Biol Interact. 2022 Sep 25;365:110076. doi: 10.1016/j.cbi.2022.110076.	`Click`