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3 Caffeoylquinic Acid, 3-Caffeoylquinic Acid, Acid, 3-Caffeoylquinic, Acid, Chlorogenic, Chlorogenic Acid

No.	Title	Href
1	Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chem Biol Interact. 2017 Jun 25;272:80-91. doi: 10.1016/j.cbi.2017.05.002.	`Click`
2	Chlorogenic Acid Enhances Doxorubicin-Mediated Cytotoxic Effect in Osteosarcoma Cells. Int J Mol Sci. 2021 Aug 10;22(16):8586. doi: 10.3390/ijms22168586.	`Click`
3	Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. Int J Mol Sci. 2018 May 19;19(5):1518. doi: 10.3390/ijms19051518.	`Click`
4	Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases. Anticancer Drugs. 2015 Jun;26(5):540-6. doi: 10.1097/CAD.0000000000000218.	`Click`

No.

Title

Href

Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chem Biol Interact. 2017 Jun 25;272:80-91. doi: 10.1016/j.cbi.2017.05.002.

Click

Chlorogenic Acid Enhances Doxorubicin-Mediated Cytotoxic Effect in Osteosarcoma Cells. Int J Mol Sci. 2021 Aug 10;22(16):8586. doi: 10.3390/ijms22168586.

Click

Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. Int J Mol Sci. 2018 May 19;19(5):1518. doi: 10.3390/ijms19051518.

Click

Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases. Anticancer Drugs. 2015 Jun;26(5):540-6. doi: 10.1097/CAD.0000000000000218.

Click

Name	Chlorogenic acid
PubChem CID	1794427
Molecular Weight	354.31g/mol
Synonyms	3 Caffeoylquinic Acid, 3-Caffeoylquinic Acid, Acid, 3-Caffeoylquinic, Acid, Chlorogenic, Chlorogenic Acid
Formula	C₁₆H₁₈O₉
SMILES	C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
InChI	1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1
InChIKey	CWVRJTMFETXNAD-JUHZACGLSA-N
CAS Number	327-97-9
ChEMBL ID	CHEMBL284616
ChEBI ID	CHEBI:16112
Drug Bank ID	DB12029
KEGG ID	C00852
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	HuangQin
Use Part	Root
Habitat	HeiLongJiang, LiaoNing, NeiMengGu, HeBei, HeNan, GanSu, Shaanxi, ShanXi, ShanDong, SiChuan
Flavor	Bitter
Meridian Tropism	Lung, Gallbladder, Spleen, Large intestine, Small intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Scutellaria 　　　　　　-->Species: Scutellaria baicalensis

Chineses Pinyin	JiXueCao
Use Part	Whole Herb With Root
Habitat	Shaanxi, JiangSu, AnHui, ZheJiang, JiangXi, HuNan
Flavor	Bitter, Pungent
Meridian Tropism	Liver, Spleen, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Centella 　　　　　　-->Species: Centella asiatica

Chineses Pinyin	JinYinHua
Use Part	Flower bud
Habitat	JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, HeBei, ShanXi, LiaoNing, Shaanxi, GanSu
Flavor	Sweet
Meridian Tropism	Lung; Stomach; Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Dipsacales 　　　　-->Family: Caprifoliaceae 　　　　　-->Genus: Lonicera 　　　　　　-->Species: Lonicera japonica

Pair Name	Chlorogenic acid, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	MAPK3	hsa5595
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	U2OS	Osteosarcoma	Homo sapiens (Human)	CVCL_0042
In Vitro Model	MG-63	Osteosarcoma	Homo sapiens (Human)	CVCL_0426
Result	These findings firstly propose CGA as a promising chemosensitizer and cardioprotective agent in OS therapy, suggesting the p44/42 MAPK pathway as relevantly involved in CGA-mediated Doxo susceptibility.

Pair Name	Chlorogenic acid, Regorafenib
Partner Name	Regorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Expression	CASP7	hsa840
In Vitro Model	PLC/PRF/5	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0485
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	This drug combination could be considered as a safe and more effective approach in HCC therapy.

Pair Name	Chlorogenic acid, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Down-regulation	Expression	MAPK1	hsa5594
Gene Regulation	Down-regulation	Expression	MAPK3	hsa5595
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
Result	CGA sensitizes hepatocellular carcinoma cells to 5-FU treatment by the suppression of ERK activation through the overproduction of ROS. CGA has shown potential as a chemosensitizer of 5-FU chemotherapy in hepatocellular carcinoma.

Pair Name	Chlorogenic acid, Methotrexate
Partner Name	Methotrexate
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	GPT	hsa2875
	Down-regulation	Expression	LDHA	hsa3939
	Down-regulation	Expression	NOS2	hsa4843
In Vivo Model	6-8 weeks old Male Wistar rats (150-200 g) were use in this study.
Result	These results imply that CGA has perfective effect against MTX-induced liver injury. Hence CGA supplementation might be helpful in abrogation of MTX toxicity.