Pair Name	Bisdemethoxycucurmin, Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis and autophagy
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Phosphorylation	ATM	hsa472
	Up-regulation	Expression	BECN1	hsa8678
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP7	hsa840
	Up-regulation	Expression	CDH1	hsa999
	Up-regulation	Phosphorylation	CHEK1	hsa1111
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Expression	DNAJB4	hsa11080
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Expression	ERBB2	hsa2064
	Up-regulation	Expression	GSK3B	hsa2932
	Up-regulation	Expression	H2AX	hsa3014
	Down-regulation	Expression	HDAC1	hsa3065
	Down-regulation	Expression	HDAC2	hsa3066
	Down-regulation	Expression	HK1	hsa3098
	Up-regulation	Expression	JUND	hsa3727
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Phosphorylation	MAPK8	hsa5599
	Down-regulation	Expression	MET	hsa4233
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	SQSTM1	hsa8878
	Up-regulation	Phosphorylation	TRIM28	hsa10155
	Up-regulation	Expression	VDAC1	hsa7416
	Down-regulation	Expression	VDAC2	hsa7417
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
	NCI-H1781	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1494
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.