| Name | Calpain-1 catalytic subunit | ||
| UniProt ID | CAN1_HUMAN | ||
| Gene Name | CAPN1 | ||
| Gene ID | 823 | ||
| Synonyms |
CAPN1, CANP, CANP1, CANPL1, SPG76, muCANP, muCL
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| Sequence |
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa823 | ||
| TTD ID | T92517 | ||
| Pfam | PF00036; PF00648; PF01067; PF13202; PF13405; PF13499; PF13833 | ||
| Pair Name | Mangiferin, Cisplatin | |||
| Phytochemical Name | Mangiferin | |||
| Anticancer drug Name | Cisplatin | |||
| Disease Info | Nephrotoxicity | Investigative | ||
| Regulate Info | Down-regulation | Calpain-1 catalytic subunit | Expression | |
| Result | The study reveals a mechanistic basis of mangiferin action against cisplatin induced nephrotoxicity. Since Mangiferin shows synergistic anticancer activity with cisplatin, it can be considered as a promising drug candidate, to be used in combination with cisplatin. | |||
