Pair Name	Sulforaphane, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	MIR30A	hsa407029
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	IGROV-1	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_1304
In Vivo Model	A2780/CP70 and IGROV1-R10 cells (4×10⁶) were injected into nude mice sub cutaneously.
Result	Our findings indicated that SFN could enhance cisplatin sensitivity of ovarian carcinoma cells through up-regulating miR-30a-3p to induce DNA damage and accumulation of intracellular cisplatin.

Pair Name	Sulforaphane, Cisplatin
Disease Info	[ICD-11: 2C28]	Malignant mesothelioma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Phosphorylation	CDK1	hsa983
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Expression	MAP1LC3B	hsa81631
In Vitro Model	NCI-H28	Pleural sarcomatoid mesothelioma	Homo sapiens (Human)	CVCL_1555
Result	Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

Pair Name	Sulforaphane, Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Up-regulation	Expression	CLDN1	hsa9076
	Up-regulation	Expression	TJP1	hsa7082
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	VIM	hsa7431
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	ZEB1	hsa6935
	Down-regulation	Expression	SNAI2	hsa6591
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	SIRT1	hsa23411
	Down-regulation	Expression	SIRT2	hsa22933
	Down-regulation	Expression	SIRT3	hsa23410
	Down-regulation	Expression	SIRT5	hsa23408
	Down-regulation	Expression	SIRT7	hsa51547
In Vitro Model	MDA-MB-468	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0419
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	The results of the current study suggests that CIS when supplemented with SFN, inhibits metastasis and stemness potential of TNBC cells by down regulating SIRTs-mediated EMT cascade. Overall this study affirms that, this novel combination could be a promising strategy against SIRT-mediated TNBC metastasis and CIS-resistance.