(15R)-cryptotanshinone, (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione, cryptotanshinon, cryptotanshinone, tanshinone C
| Name | Cryptotanshinone | ||
| PubChem CID | 160254 | ||
| Molecular Weight | 296.4g/mol | ||
| Synonyms |
(15R)-cryptotanshinone, (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione, cryptotanshinon, cryptotanshinone, tanshinone C |
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| Formula | C₁₉H₂₀O₃ | ||
| SMILES | CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C | ||
| InChI | 1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1 | ||
| InChIKey | GVKKJJOMQCNPGB-JTQLQIEISA-N | ||
| CAS Number | 35825-57-1 | ||
| ChEMBL ID | CHEMBL187460 | ||
| ChEBI ID | CHEBI:149838 | ||
| Herb ID | HBIN021795 | ||
| Drug Bank ID | DB15579 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | GanSong | ||
| Use Part | Root, Rhizome | ||
| Habitat | GanSu, QingHai, SiChuan | ||
| Flavor | Pungent, Sweet | ||
| Meridian Tropism | Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Dipsacales
-->Family: Caprifoliaceae
-->Genus: Nardostachys
-->Species: Nardostachys chinensis
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| Chineses Pinyin | DanShen | ||
| Use Part | Root | ||
| Habitat | GanSu, SiChuan, GuiZhou | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia miltiorrhiza
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| Chineses Pinyin | ZiDanCan | ||
| Use Part | Root | ||
| Habitat | AnHui, ShanXi, HeBei, SiChuan, JiangSu, HuBei, GanSu, LiaoNing, Shaanxi, ShanDong, ZheJiang, HeNan, JiangXi | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia miltiorrhiza
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| Chineses Pinyin | FuPenZi | ||
| Use Part | Aggregate Fruit | ||
| Habitat | AnHui, JiangSu, ZheJiang | ||
| Flavor | Sweet, Sour | ||
| Meridian Tropism | Liver, Kidney, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Rubus
-->Species: Rubus chingii
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| Chineses Pinyin | CaoBenWeiLingXian | ||
| Use Part | Whole Herb, Root | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, ShanDong | ||
| Flavor | Pungent, Mildly bitter | ||
| Meridian Tropism | Lung, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Plantaginaceae
-->Genus: Veronicastrum
-->Species: Veronicastrum sibiricum
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| Chineses Pinyin | ChouBai | ||
| Use Part | Branchlet-Leaf | ||
| Habitat | Shaanxi, GanSu, QingHai, NingXia, XinJiang, NeiMengGu | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Pinales
-->Family: Cupressaceae
-->Genus: Sabina
-->Species: Sabina vulgaris
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| Chineses Pinyin | GanXiShuWeiCao | ||
| Use Part | Root | ||
| Habitat | GanSu, SiChuan, YunNan, Shaanxi, GanSu, QingHai, NingXia, XinJiang, XiZang | ||
| Flavor | Bitter, Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia przewalskii
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| Chineses Pinyin | HongGenCao | ||
| Use Part | Whole Herb With Root | ||
| Habitat | JiangSu, AnHui, ZheJiang, JiangXi, HuNan, GuangDong, GuangXi | ||
| Flavor | Bitter, Mildly pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia prionitis
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| Chineses Pinyin | HuangHuaShuWeiCao | ||
| Use Part | Root | ||
| Habitat | SiChuan, YunNan | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia flava
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| Chineses Pinyin | JiMaoSong | ||
| Use Part | Branchlet-Leaf | ||
| Habitat | GuangDong, HaiNan, HaiNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Pinales
-->Family: Podocarpaceae
-->Genus: Dacrycarpus
-->Species: Dacrycarpus imbricatus
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| Chineses Pinyin | JiYeShuWeiCao | ||
| Use Part | Flower, Leaf | ||
| Habitat | YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia bulleyana
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| Chineses Pinyin | LiSeShuWeiCao | ||
| Use Part | Root | ||
| Habitat | YunNan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Liver, Kidney, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia castanea
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| Chineses Pinyin | LiuShan | ||
| Use Part | Root Cortex | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan, GuangXi, SiChuan, JiangSu, AnHui, ShanDong, HeNan | ||
| Flavor | Bitter, Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Pinales
-->Family: Cupressaceae
-->Genus: Cryptomeria
-->Species: Cryptomeria fortunei
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| Chineses Pinyin | MaoDiHuangShuWeiCao | ||
| Use Part | Root | ||
| Habitat | YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia digitaloides
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| Chineses Pinyin | NaDanShen | ||
| Use Part | Root | ||
| Habitat | ZheJiang, JiangXi, FuJian, HuNan, GuangDong, GuangXi | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia bowleyana
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| Chineses Pinyin | NiDanShen | ||
| Habitat | ZheJiang, AnHui, HuBei | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia sinica
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| Chineses Pinyin | SanYeShuWeiCao | ||
| Use Part | Root | ||
| Habitat | YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia trijuga
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| Chineses Pinyin | YunNanShuWeiCao | ||
| Use Part | Root | ||
| Habitat | YunNan, SiChuan, GuiZhou, XiZang, ChongQing | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Salvia
-->Species: Salvia yunnanensis
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| Pair Name | Cryptotanshinone, Trifluridine | |||
| Partner Name | Trifluridine | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Up-regulation | Expression | CCNB1 | hsa891 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Down-regulation | Phosphorylation | JAK2 | hsa3717 | |
| In Vitro Model | HGC-27 | Gastric carcinoma | Homo sapiens (Human) | CVCL_1279 |
| AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 | |
| In Vivo Model | After adaptive feeding for 1 week, 100 µl cell suspension of HGC-27 cells was injected into the axilla of the nude mice with a density of 4×10⁷ cells/ml. | |||
| Result | FTD combined with CTS has a synergistic anti-gastric cancer effect as shown by in vitro and in vivo experiments, and the combined treatment of FTD and CTS will be a promising treatment option for advanced gastric cancer. | |||
| Pair Name | Cryptotanshinone, Arsenic Trioxid | |||
| Partner Name | Arsenic Trioxid | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Glycolysis | |||
| Gene Regulation | Up-regulation | Phosphorylation | PRKAA1 | hsa5562 |
| Down-regulation | Expression | SLC2A1 | hsa6513 | |
| In Vitro Model | Hepa 1-6 | Hepatocellular carcinoma of the mouse | Mus musculus (Mouse) | CVCL_0327 |
| H22 | Hepatocellular carcinoma | Mus musculus (Mouse) | CVCL_H613 | |
| Result | The therapeutic potential of ACCS as a candidate option for anticancer drugs in restoring the balance of immunity and metabolism deserves further investigation. | |||
| Pair Name | Cryptotanshinone, Gefitinib | |||
| Partner Name | Gefitinib | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Down-regulation | Expression | GABPA | hsa2551 | |
| Down-regulation | Expression | TK1 | hsa7083 | |
| In Vitro Model | NCI-H1975 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1511 |
| A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| In Vivo Model | H1975 human lung cancer cells (5×10⁷ in 1 ml) or PC9/GR human lung cancer cells (3×10⁷ in 1 ml) were injected subcutaneously into the right flank of athymic BALB/c nude mice (3-4 weeks old). | |||
| Result | These findings indicated the role of TKT in lung cancer progression and may provide novel therapeutic strategies to overcome resistance to gefitinib. Furthermore, CTS may serve as a new candidate in adjuvant treatment of advanced lung cancer. | |||
| Pair Name | Cryptotanshinone, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Expression | MGMT | hsa4255 | |
| Up-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| Result | Combined treatment with CTS and TMZ might be an effective option to overcome the chemoresistance of GBM cells in a long-term treatment strategy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Effects and mechanisms of trifluridine alone or in combination with cryptotanshinone in inhibiting malignant biological behavior of gastric cancer. Cell Cycle. 2023 Jun;22(12):1463-1477. doi: 10.1080/15384101.2023.2215678. | Click |
| 2 | Arsenic Trioxide Cooperate Cryptotanshinone Exerts Antitumor Effect by Medicating Macrophage Polarization through Glycolysis. J Immunol Res. 2022 Feb 8;2022:2619781. doi: 10.1155/2022/2619781. | Click |
| 3 | Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase. Eur J Pharmacol. 2021 Jan 5;890:173647. doi: 10.1016/j.ejphar.2020.173647. | Click |
| 4 | Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells. Sci Rep. 2023 Dec 9;13(1):21835. doi: 10.1038/s41598-023-48777-z. | Click |
