Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C17]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Oxidative Stress-dependent apoptosis
Gene Regulation	Down-regulation	Expression	BIRC2	hsa329
	Up-regulation	Cleavage	CASP8	hsa841
	Down-regulation	Expression	CCR6	hsa1235
	Down-regulation	Expression	DDX3X	hsa1654
	Down-regulation	Expression	GSK3B	hsa2932
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	HuCCA-1	Intrahepatic cholangiocarcinoma	Homo sapiens (Human)	CVCL_M255
	KKU-213A	Intrahepatic cholangiocarcinoma	Homo sapiens (Human)	CVCL_M261
Result	The present study demonstrates the potential of using curcumin in combination with TRAIL to yield better TRAIL therapy outcomes in TRAIL-resistant CCA.

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	MAPK3	hsa5595
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Activity	NFKB1	hsa4790
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. The synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity