| Name | Beta-nerve growth factor | ||
| UniProt ID | NGF_HUMAN | ||
| Gene Name | NGF | ||
| Gene ID | 4803 | ||
| Synonyms |
NGF, Beta-NGF, HSAN5, NGFB
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| Sequence |
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR A |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.17.1.14; 1.B.33.1.6; 2.A.20.2.7; 2.A.57.3.3; 8.A.169.1.3; 9.B.2.1.20; 9.B.87.4.1 | ||
| KEGG ID | hsa4803 | ||
| TTD ID | T85670 | ||
| Pfam | PF00243; PF16077; PF19338; PF21500 | ||
| Pair Name | Oleuropein, Cisplatin | |||
| Phytochemical | Oleuropein | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Beta-nerve growth factor | Expression | |
| Result | Our results showed for the first time that the anti-tumor activity of oleuropein against HCC could be attributed to influencing the pro-NGF/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF. Concurrent treatment with both oleuropein and cisplatin could lead to more effective chemotherapeutic combination against HCC. | |||
