angelicin, isopsoralen
| Name | Angelicin | ||
| PubChem CID | 10658 | ||
| Molecular Weight | 186.16g/mol | ||
| Synonyms |
angelicin, isopsoralen |
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| Formula | C₁₁H₆O₃ | ||
| SMILES | C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3 | ||
| InChI | 1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H | ||
| InChIKey | XDROKJSWHURZGO-UHFFFAOYSA-N | ||
| CAS Number | 523-50-2 | ||
| ChEMBL ID | CHEMBL53569 | ||
| ChEBI ID | CHEBI:28928 | ||
| Herb ID | HBIN016087 | ||
| KEGG ID | C09060 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BuGuZhi | ||
| Use Part | Fruit | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Kidney; Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Cullen
-->Species: Cullen corylifolium
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| Pair Name | Angelicin, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C90.Z] | Renal carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| In Vitro Model | Caki-1 | Clear cell renal cell carcinoma | Homo sapiens (Human) | CVCL_0234 |
| Result | This study provides evidence that angelicin might be a TRAIL sensitizer. | |||
