| Name | Thioredoxin reductase 1 | ||
| UniProt ID | TRXR1_HUMAN | ||
| Gene Name | TXNRD1 | ||
| Gene ID | 7296 | ||
| Synonyms |
TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR, TXNR1
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| Sequence |
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa7296 | ||
| TTD ID | T84581 | ||
| Pfam | PF00070; PF00462; PF00890; PF01134; PF01262; PF01266; PF01494; PF02852; PF03486; PF05834; PF07992; PF12831; PF13450; PF13738 | ||
| Pair Name | Sulforaphane, Selenium | |||
| Phytochemical Name | Sulforaphane | |||
| Anticancer drug Name | Selenium | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Regulate Info | Up-regulation | Thioredoxin reductase 1 | Expression | |
| Result | Combined SFN and Se treatment synergistically upregulated TrxR-1, which plays a significant role in maintaining intracellular redox homeostasis and contributed to the SFN-induced protection against free radical-mediated oxidative damage in normal colonic cells. | |||
| Pair Name | Isodeoxyelephantopin, Cisplatin | |||
| Phytochemical | Isodeoxyelephantopin | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Regulate Info | Down-regulation | Thioredoxin reductase 1 | Activity | |
| Result | Our study provide a preclinical proof-of-concept for ESI as a potential strategy for colon cancer treatment. | |||
| Pair Name | Vitamin K3, Auranofin | |||
| Phytochemical | Vitamin K3 | |||
| Drug | Auranofin | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Regulate Info | Up-regulation | Thioredoxin reductase 1 | Expression | |
| Result | Our results identify TrxR1 as an attractive drug target and highlights AF as an off-patent drug candidate in GBM therapy. | |||
| Pair Name | Oleanolic Acid, Cisplatin | |||
| Phytochemical | Oleanolic Acid | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Regulate Info | Down-regulation | Thioredoxin reductase 1 | Expression | |
| Result | OLO-2 treatment also exhibited up to 4.6-fold selectivity against human lung adenocarcinoma cells. Taken together, the results of the present study shed light on the drug resistance-reversing effects of OLO-2 in lung cancer cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells. Nutr Res. 2015 Jul;35(7):610-7. doi: 10.1016/j.nutres.2015.05.011. | Click |
| 2 | Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells. Front Cell Dev Biol. 2020 Sep 22;8:580517. doi: 10.3389/fcell.2020.580517. | Click |
| 3 | Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. Int J Mol Sci. 2022 Dec 11;23(24):15712. doi: 10.3390/ijms232415712. | Click |
| 4 | Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochem Pharmacol. 2019;170:113642. doi:10.1016/j.bcp.2019.113642 | Click |
