Pair Name	Brusatol, Cytarabine
Partner Name	Cytarabine
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Gene Regulation	Down-regulation	Expression	G6PD	hsa2539
	Down-regulation	Expression	NFE2L2	hsa4780
In Vitro Model	HL-60	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_0002
	THP-1	Childhood acute monocytic leukemia	Homo sapiens (Human)	CVCL_0006
Result	Inhibition of Nrf2-mediated glucose metabolism by brusatol synergistically sensitizes acute myeloid leukemia to Ara-C

Pair Name	Brusatol, Cabergoline
Partner Name	Cabergoline
Disease Info	[ICD-11: 2F37]	Pituitary adenomas		Investigative
Biological Phenomena	Induction-->ROS accumulation
Gene Regulation	Down-regulation	Phosphorylation	EIF4EBP1	hsa1978
	Down-regulation	Expression	RHEB	hsa6009
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
In Vitro Model	GH3	Rat pituitary gland neoplasm	Rattus norvegicus (Rat)	CVCL_0273
	MMQ	Rat pituitary gland neoplasm	Rattus norvegicus (Rat)	CVCL_2117
In Vivo Model	A total of 5×10⁶ of the indicated MMQ and GH3 cells were resuspended in 100 μL PBS buffer mixed with Matrigel (1 : 1) and then subcutaneously injected into the back of each nude mice.
Result	Combined use of CAB and BT may increase the clinical effectiveness of treatment for human pituitary adenomas.

Pair Name	Brusatol, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
In Vitro Model	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
Result	These results strongly suggested that the combination of CDDP and BR was able to produce a synergistic antitumor effect in CRC cells, thus providing a solid foundation for further development of this combination regimen into an effective therapeutic method for CRC.

Pair Name	Brusatol, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	ABCC1	hsa4363
	Down-regulation	Expression	ABCC2	hsa1244
	Down-regulation	Expression	ABCC3	hsa8714
	Down-regulation	Expression	ABCC4	KEGG ID N.A.
	Down-regulation	Expression	ABCC5	KEGG ID N.A.
	Down-regulation	Expression	ABCC5	KEGG ID N.A.
	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NQO1	hsa1728
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0186
	PaTu 8988s	Pancreatic adenocarcinoma	Homo sapiens (Human)	CVCL_1846
In Vivo Model	PANC-1 cells (4×10⁶) were resuspended in 100 μL PBS and then subcutaneously injected in the right flank of nude mice.
Result	Our results suggest that brusatol is capable of enhancing the antitumour effects of gemcitabine in both pancreatic cancer cells and PANC-1 xenografts via suppressing the Nrf2 pathway.