Pair Name	Harmine, Paclitaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CDH2	hsa1000
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	FN1	hsa2335
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	PCNA	hsa5111
	Up-regulation	Expression	ROS1	hsa6098
	Up-regulation	Expression	SMAD4	hsa4089
	Down-regulation	Expression	TNF	hsa7124
	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	TWIST1	hsa7291
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
In Vivo Model	The mice were subcutaneously injected into the left axillary space with 0.1 ml of cell suspension containing 4-6×10⁶ SGC-7901 cells.
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer