InterPAD - DETAILS

tanshinone, tanshinone I, tanshinone II A, tanshinone II B, tanshinone IIA, tanshinone IIB, TTE-50

No.	Title	Href
1	Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer. Ann Transl Med. 2020 Jun;8(12):752. doi: 10.21037/atm-20-4072.	`Click`
2	Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules. Mol Biol Rep. 2018 Dec;45(6):2429-2439. doi: 10.1007/s11033-018-4409-z.	`Click`
3	Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α. Drug Des Devel Ther. 2022 Sep 19;16:3197-3213. doi: 10.2147/DDDT.S360691.	`Click`

No.

Title

Href

Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer. Ann Transl Med. 2020 Jun;8(12):752. doi: 10.21037/atm-20-4072.

Click

Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules. Mol Biol Rep. 2018 Dec;45(6):2429-2439. doi: 10.1007/s11033-018-4409-z.

Click

Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α. Drug Des Devel Ther. 2022 Sep 19;16:3197-3213. doi: 10.2147/DDDT.S360691.

Click

Name	Tanshinone I
PubChem CID	114917
Molecular Weight	276.3g/mol
Synonyms	tanshinone, tanshinone I, tanshinone II A, tanshinone II B, tanshinone IIA, tanshinone IIB, TTE-50
Formula	C₁₈H₁₂O₃
SMILES	CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C
InChI	1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChIKey	AIGAZQPHXLWMOJ-UHFFFAOYSA-N
CAS Number	568-73-0
ChEMBL ID	CHEMBL363535
ChEBI ID	CHEBI:149906
Drug Bank ID	DB16886
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	DanShen
Use Part	Root
Habitat	GanSu, SiChuan, GuiZhou
Flavor	Bitter
Meridian Tropism	Heart; Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia miltiorrhiza

Pair Name	Tanshinone I, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	CDKN2A	hsa1029
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
In Vitro Model	ID8	Epithelial Ovarian Cancer	Mus musculus (Mouse)	CVCL_IU14
In Vivo Model	The A2780 cells were injected bilaterally and subcutaneously into the flanks of the nude mice (100 µL, 2×10⁷ cells).
Result	Natural compound Tan-I enhances the efficacy of ovarian cancer to Paclitaxel chemotherapy. The results will help to supply the potential clinical use of ovarian carcinoma cells.

Pair Name	Tanshinone I, Lenalidomide
Partner Name	Lenalidomide
Disease Info	[ICD-11: 2A83.1]	Multiple myeloma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ACD	hsa65057
	Down-regulation	Expression	TERF2IP	hsa54386
	Down-regulation	Expression	TNKS	hsa8658
In Vitro Model	RPMI-8226	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0014
In Vitro Model	U266B1	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0566
Result	Combination of TanI with standard chemotherapeutic drug Len, potentiates cell death in myeloma cells

Pair Name	Tanshinone I, Epirubicin
Partner Name	Epirubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Gene Regulation	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	HIF1A	hsa3091
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
In Vivo Model	2×10⁶ HepG2 vector cells (100 μL) were injected subcutaneously into the left and right flanks of nude mice in the vector group. And 2×10*6 HepG2 HIF-1α cells (100 μL) were injected subcutaneously into the left and right flanks of nude mice in the HIF-1α group.
Result	Our results suggested that Tan I could effectively improve the anti-tumor effect of EADM, and synergize EADM to reverse HIF-1α mediated resistance via targeting PI3K/AKT/HIF-1α signaling pathway.