| Name | Telomeric repeat-binding factor 2-interacting protein 1 | ||
| UniProt ID | TE2IP_HUMAN | ||
| Gene Name | TERF2IP | ||
| Gene ID | 54386 | ||
| Synonyms |
TERF2IP, DRIP5, RAP1
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| Sequence |
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPG
AVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAE GAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSL KDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVK EEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEE EEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYP IWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa54386 | ||
| Pfam | PF08914; PF11626; PF13581; PF16589; PF17484 | ||
| Pair Name | Tanshinone I, Lenalidomide | |||
| Phytochemical | Tanshinone I | |||
| Drug | Lenalidomide | |||
| Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
| Regulate Info | Down-regulation | Telomeric repeat-binding factor 2-interacting protein 1 | Expression | |
| Result | Combination of TanI with standard chemotherapeutic drug Len, potentiates cell death in myeloma cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules. Mol Biol Rep. 2018 Dec;45(6):2429-2439. doi: 10.1007/s11033-018-4409-z. | Click |
