| Name | Adrenocortical dysplasia protein homolog | ||
| UniProt ID | ACD_HUMAN | ||
| Gene Name | ACD | ||
| Gene ID | 65057 | ||
| Synonyms |
ACD, PIP1, PTOP, TINT1, TPP1
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| Sequence |
MAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLV
SDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQV DRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQE HQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSL GPCQRTQGPELPPPDPALQDLSLTLIASPPSSPSSSGTPALPGHMSSEESGTSISLLPAL SLAAPDPGQRSSSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQA LVTRPQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAFQYEYEP PCTSLCARVQAVRLPPQLMAWALHFLMDAQPGSEPTPM |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.112.1.1; 1.A.112.1.2; 1.A.112.1.6; 1.A.6.1.4 | ||
| KEGG ID | hsa65057 | ||
| Pfam | PF07404; PF10341 | ||
| Pair Name | Tanshinone I, Lenalidomide | |||
| Phytochemical | Tanshinone I | |||
| Drug | Lenalidomide | |||
| Disease Info | [ICD-11: 2A83.1] | Multiple myeloma | Investigative | |
| Regulate Info | Down-regulation | Adrenocortical dysplasia protein homolog | Expression | |
| Result | Combination of TanI with standard chemotherapeutic drug Len, potentiates cell death in myeloma cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules. Mol Biol Rep. 2018 Dec;45(6):2429-2439. doi: 10.1007/s11033-018-4409-z. | Click |
