| Pair Name | Sulforaphane, CB-5083 | ||
| Phytochemical Name | Sulforaphane (PubChem CID: 5350 ) | ||
| Anticancer drug Name | CB-5083 (PubChem CID: 73051434 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Sulforaphane, CB-5083 | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | BCL-xL | hsa598 |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Down-regulation | Expression | EGFR | hsa1956 | |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| Up-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| Up-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| Down-regulation | Expression | TWIST1 | hsa7291 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| Result | The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Sulforaphane is Synergistic with CB-5083 and Inhibits Colony Formation of CB-5083-Resistant HCT116 Cells. ChemMedChem. 2022 Jun 3;17(11):e202200030. doi: 10.1002/cmdc.202200030. | Click |
